Results 121 to 130 of about 31,019,635 (353)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The Entropy Gain of Linear Systems and Some of Its Implications. [PDF]

Entropy (Basel), 2021
Derpich MS, Müller M, Østergaard J.
europepmc   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Some New Geometric State-Space Properties of the Classical Linear Time-Optimal Control Problem with One Input and Real Non-Positive Eigenvalues of the System Following from Pontryagin’s Maximum Principle

Axioms
This purely theoretical study considers two new geometric state-space properties of the classical linear time-optimal control problem with one input and real non-positive eigenvalues of the system, with constraints only on the control input and without ...
Borislav G. Penev
doaj   +1 more source

Dynamic Expectation Maximization Algorithm for Estimation of Linear Systems with Colored Noise. [PDF]

Entropy (Basel), 2021
Anil Meera A, Wisse M.
europepmc   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Data-Driven Parametric Modeling of Linear Systems in Frequency Domain

, 2023
Yoshihiro Matsui, Hideki Ayano, Shiro Masuda, Kazushi Nakano   +3 more
openalex   +2 more sources

State Observer for Linear Systems with Explicit Constraints: Orthogonal Decomposition Method. [PDF]

Sensors (Basel), 2021
Savin S, Balakhnov O, Khusainov R, Klimchik A.   +3 more
europepmc   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Stabilization of pilot valve system using linear flow resistance [PDF]

, 2017
Jiehong Peng, Chongho Youn, Tomoaki TAKEUCHI, Toshiharu KAGAWA   +3 more
openalex   +1 more source