Results 131 to 140 of about 12,755,747 (299)
Structure Selecting and Design Method for Control Systems Considering Plant’s Order Change
IEEE AccessIn model-based control system design, redesign is required when the order of the plant model changes. It inhibits prospective design in the control system design procedure, consisting of “plant modeling” and “controller design ...
Tatsuya Kubota +4 more
doaj +1 more source
Complete linear proofs of systems of linear inequalities
12th Annual Symposium on Switching and Automata Theory (swat 1971), 1971 Rabin has investigated the difficulty of proving that a set of linear forms is simultaneously positive by the evaluation of analytic functions. In this paper we study this same question under the restriction that each analytic function itself be linear.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Penalized ensemble Kalman filters for high dimensional non-linear systems. [PDF]
PLoS One, 2021 Hou E, Lawrence E, Hero AO.
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Computational Methods for Periodic Systems - An Overview [PDF]
, 2001 We present an up-to-date survey of numerical methods for the analysis and design of linear discrete-time periodic systems. The basic tool is the periodic Schur form and its variants, for which a certain form of numerical stability can be ...
IFAC Workshop on Periodic Control Systems (PSYCO 2001) +3 more
core
Validating Linear Systems Analysis for Laminar fMRI: Temporal Additivity for Stimulus Duration Manipulations. [PDF]
Brain Topogr, 2021 van Dijk JA +3 more
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source