Results 151 to 160 of about 5,206,394 (288)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mixed-precision iterative refinement using tensor cores on GPUs to accelerate solution of linear systems. [PDF]

Proc Math Phys Eng Sci, 2020
Haidar A, Bayraktar H, Tomov S, Dongarra J, Higham NJ.   +4 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Two-Dimensional Sampling-Recovery Algorithm of a Realization of Gaussian Processes on the Input and Output of Linear Systems. [PDF]

Entropy (Basel), 2020
Kazakov V, Enciso MA, Mendoza F.
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Optimal Sequential Fusion Kalman Filter for Multi-Sensor Linear Systems with Noise Cross-Correlated. [PDF]

Sensors (Basel)
Huang W, Wen C.
europepmc   +1 more source

Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations. [PDF]

Sci Rep, 2020
van Dijk JA, Fracasso A, Petridou N, Dumoulin SO.   +3 more
europepmc   +1 more source

How Linear Is a Linear System?

Often, when testing structures, engineers assume the experimental system only exhibits linear behavior. This linear assumption means that the modal frequency and damping of the structure do not change with response level. In many assembled structures, components are connected through bolted joints. These systems behave in a weakly nonlinear fashion due
D. Roettgen, B. Pacini, B. Moldenhauer
openaire   +2 more sources