Results 61 to 70 of about 64,093 (287)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Les apports méthodologiques et scientifiques du tracé de la LGV Le Mans-Rennes
Archéopages, 2016 The project to build the high-speed rail link Brittany-Pays de la Loire in the 2010s was preceded by a series of archaeological operations - systematic diagnostics over the 200 km of the route and excavations at around forty sites.
Nelly Le Meur, Jean-Yves Langlois
doaj +1 more source
An Influence of Trench Formation on Steel Catenary Risers Based on a Hysteretic Nonlinear Seabed Model [PDF]
Iranian Journal of Oil & Gas Science and Technology, 2017 A steel catenary riser (SCR) attached to a floating platform at its upper end encounters fluctuations in and near its touchdown zone (TDZ), which causes the interaction with the seabed. Subsea surveys and the analysis of SCR’s indicated that the greatest
Reza Siahtiri, Abdolrahim Taheri
doaj +1 more source
Architecture et réfection des aqueducs d’Orléans/Cenabum (Loiret)
Gallia, 2023 During the Early Empire, the secondary settlement of Orléans/Cenabum (France), in the territory of the city of Carnutes, covered an area of about 125 ha.
Julien Courtois +2 more
doaj +1 more source
Archaeological excavation : site of Collyhurst Old Hall [PDF]
, 2016 Salford Archaeology (SA) was commissioned by the Manchester Communications academy to undertake a community archaeological excavation on Collyhurst playing fields, Collyhurst, Manchester.
Whittall, K
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Geochemistry, Geophysics, Geosystems, 2020 Recent work suggests that slab dip may be controlled by differences in dynamic pressure above and below the slab at mid‐asthenospheric depth, motivating exploration of how plate and slab motion are linked to dynamic pressure in the asthenosphere.
Leigh H. Royden, Adam F. Holt
doaj +1 more source
Ionization versus displacement damage effects in proton irradiated CMOS sensors manufactured in deep submicron process [PDF]
, 2009 Proton irradiation effects have been studied on CMOS image sensors manufactured in a 0.18 μm technology dedicated to imaging. The ionizing dose and displacement damage effects were discriminated and localized thanks to 60Co irradiations and large ...
Bernard, Frédéric +4 more
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source