Results 71 to 80 of about 905,622 (299)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Shifting lines in D. H. Lawrence’s travel writings
E-READ.H. Lawrence (1885-1930) spent much of his life travelling around the globe, at least until his untimely death from tuberculosis. But Lawrence’s travel writing was inextricably linked with his personal philosophy, and one aspect that particularly ...
Tim GUPWELL
doaj +1 more source
Signaling pathways as linear transmitters
eLife, 2018 One challenge in biology is to make sense of the complexity of biological networks. A good system to approach this is signaling pathways, whose well-characterized molecular details allow us to relate the internal processes of each pathway to their input ...
Harry Nunns, Lea Goentoro
doaj +1 more source
Development of 2D Bi-SQUID Arrays with High Linearity
, 2013 We develop a two-dimensional (2D) Superconducting Quantum Interference Filter (SQIF) array based on recently introduced high-linearity tri-junction bi-SQUIDs.
Berggren, S. +13 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Transferring information without distortion
eLife, 2018 Despite employing diverse molecular mechanisms, many different cell signaling systems avoid losing information by transmitting it in a linear manner.
Steven S Andrews +2 more
doaj +1 more source
On the non-linearity of the subsidiary systems
, 2005 In hyperbolic reductions of the Einstein equations the evolution of gauge conditions or constraint quantities is controlled by subsidiary systems.
Friedrich, Helmut
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Linearity of stability conditions
, 2017 We study different concepts of stability for modules over a finite dimensional algebra: linear stability, given by a "central charge", and nonlinear stability given by the wall-crossing sequence of a "green path".
Igusa, Kiyoshi
core
Automatic linearity detection [PDF]
, 2013 Given a function, or more generally an operator, the question "Is it linear?" seems simple to answer. In many applications of scientific computing it might be worth determining the answer to this question in an automated way; some functionality, such as ...
Birkisson, Asgeir, Driscoll, Tobin A.
core