Results 141 to 150 of about 58,035 (315)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Error-feedback for amplifier linearization
, 1998 A novel general linearization topology called `Error-Feedback' is presented and applied to the linearization of amplifiers. Error-Feedback uses the difference/error between (linearly) scaled input and output signal in its feedback loop to reduce non ...
Meier I., De Swardt J.B.
core
Linear Characters of Finite Linear Groups
Journal of Algebra, 1999 Let \(V\) be a vector space of dimension \(n\) over the field \(\mathbb{F}_q\) of order \(q\), let \(G\) be a subgroup of \(\text{GL}(V)\), and let \(Y\) be a \(G\)-invariant subset of the set \({\mathcal P}(V)\) of \(1\)-spaces of \(V\). The author defines an \(\mathbb{F}_q^*\)-valued linear character \(\delta_Y\) related to the permutation action of \
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 1997 To maintain a high degree of reliability, the impact of major disturbances, such as a large sudden fault, should be considered during power system stabilizer design.
Bevrani, Hassan
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
H∞ Control for Systems with Mechanical Constraints Based on Orthogonal Decomposition
RoboticsIn this paper, we study H∞ control for systems with explicit mechanical constraints and a lack of state information, such as walking robots. This paper proposes an H∞ control design scheme based on solving an optimization problem with linear matrix ...
Ahmad Aldaher, Sergei Savin
doaj +1 more source
Numerical Linear Algebra in Linear Space
52 pages, 0 ...
Yiping Liu, Hoai-An Nguyen, Junzhao Yang
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