Results 61 to 70 of about 78,351 (330)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Routing in IPv6 over Low-Power Wireless Personal Area Networks (6LoWPAN): A Survey

Journal of Computer Networks and Communications, 2012
6LoWPANs (IPv6-based Low-Power Personal Area Networks) are formulated by devices that are compatible with the IEEE 802.15.4 standard. To moderate the effects of network mobility, the Internet Protocol (IP) does not calculate routes; it is left to a ...
Vinay Kumar, Sudarshan Tiwari
doaj   +1 more source

Performance and Improvement Analysis of the Underwater WSN Using a Diverse Routing Protocol Approach

Journal of Computer Networks and Communications, 2022
The planet Earth is the most water-rich place because oceans cover more than 75% of its land area. Because of the extraordinary activities that occur in the depths, we know very little about oceans.
K. Sathish, C. V. Ravikumar, Asadi Srinivasulu, A. Rajesh, Olutayo Oyeyemi Oyerinde   +4 more
doaj   +1 more source

Routing Path Assignment for Joint Load Balancing and Fast Failure Recovery in IP Network

Applied Sciences, 2021
Distributed link-state routing protocols, including Open Shortest Path First (OSPF) and Intermediate System–Intermediate System (IS-IS), have successfully provided robust shortest path routing for IP networks. However, shortest path routing is inflexible
Tabinda Ashraf, Steven S. W. Lee, Muhammad Iqbal, Jen-Yi Pan   +3 more
doaj   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Stable routing protocol for unmanned aerial vehicle ad‐hoc networks based on DQN‐OLSR

IET Communications, 2023
In unmanned aerial vehicle ad‐hoc network (UANET), the network topology changes with time due to the movement of the unmanned aerial vehicles (UAVs), which brings great challenges to the design of the routing protocol.
Youjun Zeng, Jie Zhou, Youjiang Liu, Tao Cao, Dalong Yang, Yu Liu, Xianhua Shi   +6 more
doaj   +1 more source

An Experimental Investigation of Hyperbolic Routing with a Smart Forwarding Plane in NDN

, 2016
Routing in NDN networks must scale in terms of forwarding table size and routing protocol overhead. Hyperbolic routing (HR) presents a potential solution to address the routing scalability problem, because it does not use traditional forwarding tables or
Aldecoa, Rodrigo, Gawande, Ashlesh, Krioukov, Dmitri, Lehman, Vince, Wang, Lan, Zhang, Beichuan, Zhang, Lixia   +6 more
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source