Results 111 to 120 of about 7,799,039 (309)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Link Prediction in Stagewise Graphs
IEEE Transactions on Knowledge and Data EngineeringA stagewise graph has distinct edge types that represent the different stages. Two nodes can be connected by an edge of the current stage only if an edge of the preceding one is already connecting them. Stagewise graphs can represent many kinds of interactions.
Pieter Dewulf +2 more
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Hypergraph Neural Networks Based on Enclosing Subgraph Extraction for Temporal Link Prediction
IEEE AccessThe Graph Neural Network (GNN) methods based on enclosing subgraph extraction have achieved excellent results in static graph link prediction tasks. However, most real-world networks are dynamic and evolve over time; the traditional models cannot capture
Ying Zhao +4 more
doaj +1 more source
Reevaluation of Inductive Link Prediction
Within this paper, we show that the evaluation protocol currently used for inductive link prediction is heavily flawed as it relies on ranking the true entity in a small set of randomly sampled negative entities. Due to the limited size of the set of negatives, a simple rule-based baseline can achieve state-of-the-art results, which simply ranks ...
Simon Ott +2 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Ego-net link prediction with GNN
Научно-технический вестник информационных технологий, механики и оптикиThe task of link prediction is one of the key challenges in the field of social network analysis. The common way to build such systems is based on the idea of decomposing a task into two levels. At the first level, links within ego-nets are predicted; at
E. I. Zamyatin
doaj +1 more source
Link Prediction via Generalized Coupled Tensor Factorisation
, 2012 This study deals with the missing link prediction problem: the problem of predicting the existence of missing connections between entities of interest. We address link prediction using coupled analysis of relational datasets represented as heterogeneous ...
Acar, Evrim +2 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Gravity-Inspired Graph Autoencoders for Directed Link Prediction
, 2019 Graph autoencoders (AE) and variational autoencoders (VAE) recently emerged as powerful node embedding methods. In particular, graph AE and VAE were successfully leveraged to tackle the challenging link prediction problem, aiming at figuring out whether ...
Hennequin, Romain +4 more
core