Results 111 to 120 of about 64,504 (272)
There are 130,000 adults living with cerebral palsy (CP) in the UK. People ageing with CP can experience unequal opportunities throughout their life which become amplified in older age.
Valerie Stevenson +8 more
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Labor Market Flows in the Cross Section and Over Time [PDF]
Many theoretical models of labor market search imply a tight link between worker flows (hires and separations) and job gains and losses at the employer level. Partly motivated by these theories, we exploit establishment-level data from U.S.
Steven J. Davis +2 more
core
Social worker's experiences of linking theory and practice
, 2012 This article presents the findings of a Bachelor of Social Work honours research project that explored the importance of theoretical knowledge and the relationship between theory and practice for social workers in the field of health in the ACT and surrounding NSW.
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Glasgow City HSCP Community Link Worker programme annual report 2024 / 2025
Primary Care Community Link Workers (CLWs*) are funded as part of Glasgow City Health & Social Care Partnership’s Primary Care Improvement Plan. This report focusses on the work of Primary Care CLWs and specialist thematic CLWs, and details the progress ...
Bissett, Nicola
core
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
This study aims to optimise the uptake and adherence to physical activity-based interventions by understanding how to ensure that meaningful, effective and evidence-based conversations about physical activity happen during patient and link worker ...
Stephanie Tierney +3 more
core