Results 141 to 150 of about 64,504 (272)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The link between firm-level innovation and aggregate productivity growth: a cross-country examination [PDF]

This paper investigates whether failure in innovation at the firm level can account for cross-country heterogeneity in manufacturing productivity growth. There is no strong evidence in the literature on the existence of such link.
Heshmati, Almas, Lööf, Hans
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Feasibility study and process evaluation of the CP Link Worker intervention

The overarching aim of this study is to assess the feasibility of delivering a specialised link worker intervention for middle-aged and older adults with cerebral palsy living in North Central London.
Valerie Stevenson, Kimberley Smith, Emma Livingstone, Miriam Creeger, Erica Ranzato, Meriel Norris, Karen Lowton, Cherry Kilbride, Christina Victor   +8 more
core   +1 more source

Impact of the rollout of the national social prescribing link worker programme on population outcomes: evidence from a repeated cross-sectional survey. [PDF]

Br J Gen Pract
Wilding A, Agboraw E, Munford L, Sutton M, Mercer SW, Salisbury C, Beeson M, Wildman J, Wilson P.   +8 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Development of a community research link worker role to enable culturally tailored research and empower marginalised communities to participate: the IBISES model. [PDF]

Res Involv Engagem
Fryer K, Reynolds J, Huang Q, Mawson R, Linton E, Aminu H, White J, Cory R, Mitchell C, University of Sheffield, Leeds University, Sheffield Chinese Community Centre, Sheffield African Caribbean Mental Health Association, Shipshape, Children and Young People’s Futures, Rosasencis Productions.   +15 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Entering a liminal state when becoming a social prescribing link worker and how it affects retention: findings from a UK qualitative study. [PDF]

Prim Health Care Res Dev
Tierney S, Moore L, Westlake D, Dawson S, Fuller E, Husk K, Nunan D, Roberts P, Sabir L, Smith JR, Ukoumunne OC, Mahtani KR.   +11 more
europepmc   +1 more source