Results 91 to 100 of about 4,509,754 (266)

Record-Linkage from a Technical Point of View [PDF]

TRecord linkage is used for preparing sampling frames, deduplication of lists and combining information on the same object from two different databases.
Rainer Schnell
core  

Detecting referral and selection bias by the anonymous linkage of practice, hospital and clinic data using Secure and Private Record Linkage (SAPREL): case study from the evaluation of the Improved Access to Psychological Therapy (IAPT) service. [PDF]

, 2011
BACKGROUND: The evaluation of demonstration sites set up to provide improved access to psychological therapies (IAPT) comprised the study of all people identified as having common mental health problems (CMHP), those referred to the IAPT service, and a ...
Parry, G., Dent-Brown, Kim, Kendrick, Tony, Dent-Brown, K., Tony Kendrick, Dent-Brown, K, Dent-Brown Kim, de Lusignan, S., Navarro, R, Kendrick Tony, Chan, Tom, Glenys Parry, Chan Tom, Navarro, R., Kendrick, T, Chan, T., Navarro, Rob, Kim Dent-Brown, Parry, G, Navarro Rob, Simon de Lusignan, Chan, T, Parry, Glenys, Kendrick, T., de Lusignan Simon, de Lusignan, S, Parry Glenys, de Lusignan, Simon, Tom Chan, Rob Navarro   +29 more
core   +2 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Linking the National Down Syndrome Cytogenetic Register to Hospital Episode Statistics: Methods and challenges

International Journal of Population Data Science, 2018
Background Linking national disease and congenital anomaly registers to other routinely collected data could provide multiple benefits. It could allow researchers to examine long-term outcomes for people with registered conditions and to explore ...
James Doidge, Joan Morris, Ruth Gilbert
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

EUPID—configurable privacy-preserving record linkage in federated health data spaces

Frontiers in Digital Health
IntroductionRare disease research relies heavily on secondary use of health data due to the scarcity of clinical guidelines and data sharing between research institutions and hospitals.
Dieter Hayn, Dieter Hayn, Emanuel Sandner, Martin Baumgartner, Bernhard Jammerbund, Fabian Wiesmüller, Fabian Wiesmüller, Stefan Beyer, Stefan Beyer, Hannah Vinatzer, Hannah Vinatzer, Angelika Rzepka, Klaus Donsa, Karl Kreiner, Guenter Schreier, Guenter Schreier   +15 more
doaj   +1 more source

Probabilistic record linkage and an automated procedure to minimize the undecided-matched pair problem [PDF]

Probabilistic record linkage allows the assembling of information from different data sources. In this article, we present a procedure in case a one-to-one relationship between records in different files is expected but is not found only by applying the ...
Kenneth Hill, Carla Jorge Machado
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source