Results 101 to 110 of about 4,509,754 (266)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Other title: Kansas Department for Aging and Disability Services Update; Other title: Update

, 2017
"April 19, 2017."Presentation before the Kansas Legislature, Robert G. Bethell Joint Committee on Home and Community Based Services and KanCare Oversight, presented by the Kansas Department for Aging and Disability Services.Presentation giving statistics
Kansas. Department for Aging and Disability Services.
core   +1 more source

Cost analysis of two community-based HIV testing service modalities led by a Non-Governmental Organization in Cape Town, South Africa

BMC Health Services Research, 2017
Background In South Africa, the financing and sustainability of HIV services is a priority. Community-based HIV testing services (CB-HTS) play a vital role in diagnosis and linkage to HIV care for those least likely to utilise government health services.
Sue-Ann Meehan, Nulda Beyers, Ronelle Burger   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Unlocking the potential of health systems using privacy preserving record linkage: A pilot project exploring the research potential of developing a linkable general practice dataset

International Journal of Population Data Science, 2019
Background General practice is a rich source of health data for research. It is an important resource which can be used to improve patient management, reduce costs and improve patient outcomes.
James Boyd, Yuen Ai Lee, Adrian Brown, Sean Randall, Anna Ferrante   +4 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Consumer handbook for vocational rehabilitation services. 2012: Oct.

, 2003
Title from PDF cover (viewed May 18, 2007).; "May 2003."; This handbook is designed to provide general information about the vocational rehabilitation program offered through the Connecticut Dept.
Connecticut. Bureau of Rehabilitation Services.
core   +1 more source

Exploring the feasibility of Recovery Management Checkups for Primary Care in a Federally Qualified Health Center

Frontiers in Public Health
IntroductionPrimary care settings present an opportunity for alcohol and substance use disorder (A/SUD) screening and treatment referral. However, there are recognized deficiencies in widely used treatment referral approaches, including acute care ...
Dennis P. Watson, Ryan Singh, Lisa Taylor, Michael L. Dennis, Christine E. Grella, Carol Johnstone, Katherine Browne, Lisa Saldana   +7 more
doaj   +1 more source