Results 121 to 130 of about 1,334,769 (343)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Superrotations are linkages

Physical Review D
We show that superrotations can be described using the geometric conformal completion method of Penrose. In particular, superrotation charges and fluxes can be described and calculated using the linkage method of Geroch and Winicour. Whether superrotation charges are calculated using the coordinate based Bondi formalism or the geometric Penrose ...
Ratindranath Akhoury, Arielle Schutz, David Garfinkle   +2 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

PLINK: a tool set for whole-genome association and population-based linkage analyses.

American Journal of Human Genetics, 2007
S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, Manuel A. R. Ferreira, David P Bender, J. Maller, P. Sklar, P. D. de Bakker, M. Daly, P. Sham   +10 more
semanticscholar   +1 more source

Record Linkage of the Linked Employer-Employee Survey of the Socio-Economic Panel Study (SOEP-LEE) and the Establishment History Panel (BHP) [PDF]

, 2016
Eberle J, Weinhardt M. Record Linkage of the Linked Employer-Employee Survey of the Socio-Economic Panel Study (SOEP-LEE) and the Establishment History Panel (BHP). German Record Linkage Center. Working Paper Series . Vol WP-GRLC-2016-01.
Eberle, Johanna, Weinhardt, Michael
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

MapChart: software for the graphical presentation of linkage maps and QTLs.

Journal of Heredity, 2002
R. Voorrips
semanticscholar   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mapping genomic regions for reproductive stage drought tolerance in rice from exotic landrace-derived population

Frontiers in Plant Science
In the rapid climate change scenario and subsequent rainfall patterns, drought has emerged as a bottleneck for crop production across crops, especially in rainfed rice.
Challa Venkateshwarlu, Challa Venkateshwarlu, Paresh Chandra Kole, Arun Kumar Singh, Pronob J. Paul, Pallavi Sinha, Vikas Kumar Singh, Arvind Kumar   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source