Results 101 to 110 of about 1,334,769 (343)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Detecting referral and selection bias by the anonymous linkage of practice, hospital and clinic data using Secure and Private Record Linkage (SAPREL): case study from the evaluation of the Improved Access to Psychological Therapy (IAPT) service. [PDF]

, 2011
BACKGROUND: The evaluation of demonstration sites set up to provide improved access to psychological therapies (IAPT) comprised the study of all people identified as having common mental health problems (CMHP), those referred to the IAPT service, and a ...
Parry, G., Dent-Brown, Kim, Kendrick, Tony, Dent-Brown, K., Tony Kendrick, Dent-Brown, K, Dent-Brown Kim, de Lusignan, S., Navarro, R, Kendrick Tony, Chan, Tom, Glenys Parry, Chan Tom, Navarro, R., Kendrick, T, Chan, T., Navarro, Rob, Kim Dent-Brown, Parry, G, Navarro Rob, Simon de Lusignan, Chan, T, Parry, Glenys, Kendrick, T., de Lusignan Simon, de Lusignan, S, Parry Glenys, de Lusignan, Simon, Tom Chan, Rob Navarro   +29 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Improvement of visual accentivation public corridors the Old Downtown area of Banda Aceh

ARTEKS : Jurnal Teknik Arsitektur, 2017
Kawasan pusat kota lama Banda Aceh menyimpan nilai sejarah yang tinggi, terbukti dengan banyaknya peninggalan-peninggalan bersejarah yang masih bertahan sebagai objek bersejarah di kawasan ini. Keberadaan artefak-artefak kuno ini dapat melengkapi riwayat
Indah Keumala
doaj   +1 more source

Adaptive Linkage Crossover

Evolutionary Computation, 1998
Problem-specific knowledge is often implemented in search algorithms using heuristics to determine which search paths are to be explored at any given instant. As in other search methods, utilizing this knowledge will more quickly lead a genetic algorithm (GA) towards better results.
Ayed A. Salman, Kishan Mehrotra, Chilukuri K. Mohan   +2 more
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Maternal mortality: data linkage methodology [PDF]

, 2014
The report presents a data linkage methodology to ascertain the number of maternal and late maternal deaths in Australia. It is one of several components of the National Maternity Data Development Project and is a companion report to the publication ...

core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A co-produced framework for assessing common law basis of consent to enable record linkage for public good research

International Journal of Population Data Science
Objective UK-wide Longitudinal Population Studies (LPS) have been brought together and linked to NHS, socioeconomic records and environmental data within a Trusted Research Environment.
Jacqui Oakley
doaj   +1 more source