Results 221 to 230 of about 1,508,074 (296)

Integrating postal HIV testing into the HIV care cascade in Japan: a public health centre model. [PDF]

J Int AIDS Soc
Iwahashi K, Ejima K, Tsuchiya N, Phanuphak N, Imamura A.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Discovery of Novel Minor Steviol Glycoside from the <i>Stevia rebaudiana</i>: Structural Characterization and Proposed Biosynthetic Pathway of Rebaudioside <i>D17</i>. [PDF]

Biomolecules
Wong XJ, Nawi KNB, Wong YY, Mohamat IAB, Ramandach S, Bin Hasim MA, Markosyan A.   +6 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Genetic mapping, marker development, and identification of candidate genes for powdery mildew resistance in <i>Malus baccata</i> 'Jackii'. [PDF]

Front Plant Sci
Pfeifer M, Kurzweg L, Muçaj B, Burkhardt T, Peil A, Flachowsky H, Emeriewen OF, Wöhner TW.   +7 more
europepmc   +1 more source

Emergency Department Presentations and Hospitalisations for Elder Abuse in People Accessing Aged Care Services in Australia: A Retrospective Cross-Sectional Study. [PDF]

Med J Aust
Harrison SL, Barmomanesh S, Morden B, Inacio MC, Caughey GE, ROSA Consumer and Community Advisory Committee.   +5 more
europepmc   +1 more source

Quantitative lipidomic analysis of blood and milk in jennies with high and low milk fat content. [PDF]

Vet Anim Sci
Zhang LT, Zhang K, Yan QX, Deng L, Degen A, Liu LL, Zhou XL.   +6 more
europepmc   +1 more source