Results 61 to 70 of about 1,334,769 (343)

Unleashing The Power of Your Master Linkage Map – Is There A Role For Business Intelligence Tools In Supporting Data Linkage?

International Journal of Population Data Science, 2019
Background with rationale Business Intelligence (BI) software applications collect and process large amounts of data from one or more sources, and for a variety of purposes. These can include generating operational or sales reports, developing dashboards
Brian Stokes
doaj   +1 more source

The Genetics of Human Schistosomiasis Infection Intensity and Liver Disease: A Review

Frontiers in Immunology, 2021
Schistosomiasis remains the fourth most prevalent parasitic disease affecting over 200 million people worldwide. Control efforts have focussed on the disruption of the life cycle targeting the parasite, vector and human host.
Estelle M. Mewamba, Oscar A. Nyangiri, Harry A. Noyes, Moses Egesa, Moses Egesa, Enock Matovu, Gustave Simo   +6 more
doaj   +1 more source

Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2 [PDF]

, 2005
Background: In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study.Methods: DNA from eighteen families, densely affected by alcoholism, was used to genotype a set of polymorphic ...
Devitgh, Audrey, Kest, Wendy, Kest Wendy, Devitgh, A, McQuillin Andrew, Cook Christopher CH, McQuillin, Andrew, Gurling Hugh MD, Curtis, David, Gurling, Hugh M.D., Cook, Christopher C.H., Devitgh Audrey, Gurling, HMD, Guerrini, Irene, Curtis, D, Curtis David, McQuillin, A, Guerrini, I, Cook, CCH, Guerrini Irene, Kest, W   +20 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Evaluating privacy-preserving record linkage using cryptographic long-term keys and multibit trees on large medical datasets

BMC Medical Informatics and Decision Making, 2017
Background Integrating medical data using databases from different sources by record linkage is a powerful technique increasingly used in medical research.
Adrian P. Brown, Christian Borgs, Sean M. Randall, Rainer Schnell   +3 more
doaj   +1 more source

Suicide Prevention Interventions and Their Linkages in Multilayered Approaches for Older Adults: A Review and Comparison

Frontiers in Public Health, 2022
Multilayered approaches to suicide prevention combine universal, selective, and indicated prevention interventions. These approaches may be more successful in reducing suicide rates among older adults if they link these layers more systematically: that ...
Tomoe Sakashita, Hirofumi Oyama
doaj   +1 more source

Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion [PDF]

, 1998
Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Zöllner, Sebastian, Laan, Maris, Terwilliger, J., Zöllner, S., Pääbo, S. ; https://orcid.org/, Pääbo, Svante, Laan, M., Terwilliger, Joseph D., Terwilliger, J. D., Maris Laan, Sebastian Zöllner, Joseph D. Terwilliger, Svante Pääbo   +12 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The effect of cross-jurisdictional linked hospital and death data on estimating risk-adjusted grouped hospital standardised mortality ratios in Australia

International Journal of Population Data Science, 2017
Objectives The Population Health Research Network (PHRN) was established to increase data linkage capacity in Australia. A proof of concept study investigating cross border hospital use and hospital mortality was undertaken to demonstrate the ...
Katrina Spilsbury, Anna Ferrante, Diana Rosman, Janine Alan, James Boyd, James Semmens   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source