Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Probabilistic record linkage and an automated procedure to minimize the undecided-matched pair problem [PDF]
Probabilistic record linkage allows the assembling of information from different data sources. In this article, we present a procedure in case a one-to-one relationship between records in different files is expected but is not found only by applying the ...
Kenneth Hill, Carla Jorge Machado
core
Developing client-based analyses for reporting on the alcohol and other drug treatment services [PDF]
, 2013 This paper outlines intended analysis techniques to estimate the number and rate of clients receiving alcohol and other drug treatment, to explore patterns of drug use and pathways through treatment, and to explore the characteristics of different client
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Quantification of the mobility potential of antibiotic resistance genes through multiplexed ddPCR linkage analysis. [PDF]
FEMS Microbiol Ecol, 2023 de la Cruz Barron M +5 more
europepmc +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
The preimplantation genetic testing for monogenic disorders strategy for blocking the transmission of hereditary cancers through haplotype linkage analysis by karyomapping. [PDF]
J Assist Reprod Genet, 2023 Chen C +7 more
europepmc +1 more source
Predicting impact conditions due to bearing clearances in linkage mechanisms. [PDF]
, 1978 PhDClearances at connections of mechanical systems may allow contact to be momentarily lost between the interconnected elements resulting in impact loading, the generation of noise and deterioration of the bearing surfaces.
Kiliçay, Ö
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Integrated Linkage Analysis System for Locomotive Operation Information
机车电传动, 2018 Aiming at the problems of current locomotive operation information decentralization and independence, different information standards of the same kind, various analysis software, independent analysis posts, backward audio and video information storage ...
ZENG Youheng, CHEN Lin, HUANG Qiang
doaj