Results 201 to 210 of about 2,559,621 (312)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Linkage map construction and QTL mapping for morphological traits in Ipomoea trifida, a diploid sweetpotato relative. [PDF]

Plant Genome
Alves da Mata AP, Gemenet DC, Diaz F, David M, Mosquera V, Bachega Feijó Rosa JR, Gonçalves Dos Santos I, de Siqueira Gesteira G, Mollinari M, Khan A, Yencho GC, Zeng ZB, da Silva Pereira G.   +12 more
europepmc   +1 more source

An Integrated Linkage Map of Three Recombinant Inbred Populations of Pea (Pisum sativum L.). [PDF]

Genes (Basel), 2022
Sawada C, Moreau C, Robinson GHJ, Steuernagel B, Wingen LU, Cheema J, Sizer-Coverdale E, Lloyd D, Domoney C, Ellis N.   +9 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Predominantly Independent Genetic Control Between Growth and Visceral White Nodules Disease Resistance Revealed by High-Density Linkage Map and QTL Mapping in <i>Larimichthys crocea</i>. [PDF]

Int J Mol Sci
Ye T, Guo D, Zhou Y, Lou B, Liu F.
europepmc   +1 more source

A Novel Strategy for Constructing an Integrated Linkage Map in an F₁ Hybrid Population of Populus deltoides and Populus simonii. [PDF]

Genes (Basel), 2022
Li Z, Zhang J, Pan Z, Bai S, Tong C.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Development of a Flex-Seq SNP panel for raspberry (Rubus idaeus L.) and validation through linkage map construction and identification of QTL for several traits of agronomic importance to raspberry breeding. [PDF]

PLoS One
Davik J, Zucchi P, Buti M, Milne L, Graham J, Sargent DJ.   +5 more
europepmc   +1 more source

Molecular Mapping of Biofortification Traits in Bread Wheat (Triticum aestivum L.) Using a High-Density SNP Based Linkage Map. [PDF]

Genes (Basel), 2023
Jadon V, Sharma S, Krishna H, Krishnappa G, Gajghate R, Devate NB, Panda KK, Jain N, Singh PK, Singh GP.   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source