Results 341 to 350 of about 2,105,476 (389)
Some of the next articles are maybe not open access.
Haplotype bolck linkage disequilibrium mapping
Frontiers in Bioscience, 2003Linkage disequilibrium (LD) mapping is emerging as a powerful alternative approach to identifying genes for complex disease. However, the feasibility and success of LD mapping depend largely on the extent and pattern of LD. Erratic pattern of pair-wise LD seriously compromises LD mapping.
Momiao, Xiong +2 more
openaire +2 more sources
Linkage maps of human chromosomes
Genome, 1989Finding the chromosomal location of human genes that heretofore have been defined solely by phenotypes, in particular clinical phenotypes that are transmitted in Mendelian fashion in families, is an early and often crucial step in the process of identifying the molecular basis of a disease.
R, White +5 more
openaire +2 more sources
2010
Linkage maps provide information not only on the linear order of genetic loci on chromosomes; they also reveal the locations and frequencies of crossover events during gametogenesis. As such they have been invaluable resources for genetic mapping for nearly 100 years and continue to be extremely useful for providing insight into the meiotic process and
openaire +1 more source
Linkage maps provide information not only on the linear order of genetic loci on chromosomes; they also reveal the locations and frequencies of crossover events during gametogenesis. As such they have been invaluable resources for genetic mapping for nearly 100 years and continue to be extremely useful for providing insight into the meiotic process and
openaire +1 more source
Linkage Disequilibrium Mapping
2004Abstract Chapter 8 dealt with the origins and evolution of LD and Chapter 9 with cohort and case-control designs for testing associations between a disease and a genetic marker, which could be applied to proposed causal (candidate) genes or to markers not thought to be causal themselves but perhaps in LD with a causal gene being ...
openaire +1 more source
2012
Genome mapping methods are generally divided into two categories: (1) genetic or linkage mapping and (2) physical mapping. Genetic mapping is based on the use of genetic techniques to construct maps showing the positions of genes and other sequence features on a genome, whereas physical maps are constructed by directly sequencing DNA molecules, and ...
openaire +1 more source
Genome mapping methods are generally divided into two categories: (1) genetic or linkage mapping and (2) physical mapping. Genetic mapping is based on the use of genetic techniques to construct maps showing the positions of genes and other sequence features on a genome, whereas physical maps are constructed by directly sequencing DNA molecules, and ...
openaire +1 more source
Linkage Disequilibrium Maps and Disease-Association Mapping
2007Over the last few years, association mapping of disease genes has developed into one of the most dynamic research areas of human genetics. It focuses on identifying functional polymorphisms that predispose to complex diseases. Population-based approaches are concerned with exploiting linkage disequilibrium (LD) between single-nucleotide polymorphism ...
openaire +3 more sources
1997
Abstract The basic principles of linkage mapping have been used by scientists for many years, to establish whether a particular disease is associated with a specific chromosomal region. Linkage amongst simple Mendelian traits is often observable at the phcnotypic level.
openaire +1 more source
Abstract The basic principles of linkage mapping have been used by scientists for many years, to establish whether a particular disease is associated with a specific chromosomal region. Linkage amongst simple Mendelian traits is often observable at the phcnotypic level.
openaire +1 more source
Linkage Disequilibrium and Association Mapping
Annual Review of Genomics and Human Genetics, 2008Linkage disequilibrium refers to the association between alleles at different loci. The standard definition applies to two alleles in the same gamete, and it can be regarded as the covariance of indicator variables for the states of those two alleles. The corresponding correlation coefficient ρ is the parameter that arises naturally in discussions of ...
openaire +2 more sources