Results 181 to 190 of about 588,273 (328)

Short communication: Characterization of the genome-wide linkage disequilibrium in 2 divergent selection lines of dairy cows [PDF]

, 2010
Banos, G., Coffey, M. P.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A public mid-density genotyping platform for cultivated cranberry (Vaccinium macrocarpon Aiton). [PDF]

Plant Genome
Chen S, Lin M, Taniguti CH, Tang X, de la Torre F, Sideli GM, Iorizzo M, Edger PP, Neyhart J, Zalapa J, Bassil N, Heller-Uszynska K, Zhao D, Beil CT, Sheehan MJ.   +14 more
europepmc   +1 more source

Case study on communicating with research ethics committees about minimizing risk through software: an application for record linkage in secondary data analysis [PDF]

Cason Schmit, Alva O. Ferdinand, Theodoros V. Giannouchos, Hye‐Chung Kum   +3 more
openalex   +1 more source

Avaliação do sistema de vigilância em saúde do trabalhador relacionada aos acidentes de trabalho, antes e após a implantação do software de linkage Sentinela, em Porto Alegre, 2018-2021

, 2023
Fabiana Hermes Suprinyak, Ivone Andreatta Menegolla   +1 more
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Genomic sequencing combined with marker-assisted breeding effectively eliminates potential linkage drag of a target gene: a case study in tobacco. [PDF]

Front Plant Sci
Gao W, Yu W, Lin J, Zhao Z, Yin N, Lai J, Cheng Y, Huang L, Li C, Chen S, Wu W, Wu S.   +11 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Optimization of the Mainzelliste Software for Fast Privacy-preserving Record Linkage

, 2020
Florens Rohde, Martin Franke, Ziad Sehili, Martin Lablans, Erhard Rahm   +4 more
openalex   +4 more sources

Genetic architecture of the Sindhi Indian population: a 19X-STR forensic analysis. [PDF]

BMC Genomics
Gautam K, Devnani C, Dasgupta S, Nandineni MR, Thangaraj K, Chaubey G, Rawal R.   +6 more
europepmc   +1 more source