Results 191 to 200 of about 604,743 (325)

First High-Density Linkage Map and Quantitative Trait Loci for Disease Resistance in Striped Catfish <i>Pangasianodon hypophthalmus</i>. [PDF]

Int J Mol Sci
Vu NT, Phuc TH, Huong TTM, Nguyen NH.
europepmc   +1 more source

Fit for purpose - developing a software platform to support the modern challenges of data linkage in Western Australia

, 2018
Tom Eitelhuber, James Thackray, Steve J. Hodges, Janine Alan   +3 more
openalex   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Integrative linkage and recombination analysis of 25 X-STRs across 7 linkage groups using pedigree-based and SNP-based strategies. [PDF]

Front Genet
Qian J, Qian X, Ji Q, Li Z, Shao C, Xu H, Yang F, Xie J.   +7 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Growth-Rate Related Quantitative Trait Locus Analysis of Monokaryotic Isolates of <i>Grifola albicans</i> f. <i>huishuhua</i> (Maitake). [PDF]

J Fungi (Basel)
Zhang P, Wang J, Li G, Xiao S, Sun L, Li X, Tian J, Li M, Li S.   +8 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Cross-Software Radiomic Feature Robustness Assessed by Hierarchical Clustering and Composite Index Analysis: A Multi-Cancer Study on Colorectal and Liver Lesions. [PDF]

Bioengineering (Basel)
Fusco R, Festa G, Sansone M, Setola SV, Avallone A, Izzo F, Petrillo A, Granata V.   +7 more
europepmc   +1 more source

Cytonuclear linkage disequilibrium between <i>A. icterica</i> mitochondrial lineages and microsatellite alleles, estimated using CNDm software (Basten & Asmussen 1997).

, 2015
Torres-Leguizamon Magally, Jérôme Mathieu, D Thibaud, Lise Dupont   +3 more
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source