Results 201 to 210 of about 30,884,827 (363)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Mediation of socioeconomic inequalities in preterm birth. A cohort analysis of Welsh linked data. [PDF]

Acta Obstet Gynecol Scand
McHale P, Schlüter DK, Abbasizanjani H, Akbari A, Barr B, Taylor-Robinson D.   +5 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Factors associated with diagnostic and treatment intervals in colorectal cancer: A linked data study. [PDF]

Int J Cancer
Drosdowsky A, Lamb KE, Te Marvelde L, Gibbs P, Dunn C, Faragher I, Jones I, IJzerman MJ, Emery JD.   +8 more
europepmc   +1 more source

Fourteen quick tips for crowdsourcing geographically linked data for public health advocacy. [PDF]

PLoS Comput Biol, 2023
Atienza J, Benedict A, Stein LD, Pirzada K, White C, Pai S.   +5 more
europepmc   +1 more source

Heritage Weaver: Classifying, Searching, and Linking Museum Data with Multimodal AI [PDF]

Kaspar Beelen, Natasha Kitcher
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Linked Data

IEICE Communications Society Magazine, 2013
openaire   +3 more sources

Recurrent care proceedings and use of services for substance use disorder: A retrospective linked data cohort study of mothers in South London. [PDF]

Addiction
Canfield M, Gilchrist G, Downs J, Norton S.   +3 more
europepmc   +1 more source

Links to data

, 2020
openaire   +2 more sources