The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh+6 more
wiley +1 more source
Changes in comprehensiveness of services delivered by Canadian family physicians: Analysis of population-based linked data in 4 provinces. [PDF]
Lavergne MR+19 more
europepmc +1 more source
PMC4: LINKING HRQOLS TO LARGE NATIONAL DATA SETS: EUROQOL AND HUI INDICES
JA Rizzo, JL Sindelar
openalex +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi+26 more
wiley +1 more source
MonARCh: an actor based architecture for dynamic linked data monitoring. [PDF]
Yönyül B, Alatlı O, Erdur RC.
europepmc +1 more source
Developing a risk prediction tool for lung cancer in Kent and Medway, England: cohort study using linked data. [PDF]
Howell D+7 more
europepmc +1 more source
Temporal and spatial modelling of tropical deforestation: a survival analysis linking satellite and household survey data [PDF]
Colin Vance, Jacqueline Geoghegan
openalex +1 more source
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam+9 more
wiley +1 more source
Recognition of ophthalmology consultation and fundus examination among individuals with diabetes in Japan: A cross-sectional study using claims-questionnaire linked data. [PDF]
Yamamoto K+10 more
europepmc +1 more source