Results 101 to 110 of about 3,042,480 (332)

Publishing and linking transport data on the Web [PDF]

arXiv, 2012
Without Linked Data, transport data is limited to applications exclusively around transport. In this paper, we present a workflow for publishing and linking transport data on the Web. So we will be able to develop transport applications and to add other features which will be created from other datasets.
arxiv  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Semantic Web: Metadata, Linked Data, Open Data

Science & Philosophy, 2015
What's the Semantic Web? What's the use? The inventor of the Web Tim Berners-Lee describes it as a research methodology able to take advantage of the network to its maximum capacity.
Vanessa Russo
doaj  

Linked Open Government Data Analytics [PDF]

, 2013
Although the recently launched Open Government Data (OGD) movement promised to provide a number of benefits, recent studies have shown that its full potential has not yet realized. The difficulty in exploiting open data seems surprising if we consider the huge importance data have in modern societies.
Kalampokis, Evangelos, Tambouris, Efthimios, Tarabanis, Konstantinos   +2 more
openaire   +3 more sources

NameSampo: A Linked Open Data Infrastructure and Workbench for Toponomastic Research

GeoHumanities@SIGSPATIAL, 2018
This paper presents a series of projects where one of the main sources for toponomastic research in Finland, the corpora of 2.7 million place names in the Names Archive database of the Institute for the Languages of Finland, was digitized, enriched, and ...
Esko Ikkala, J. Tuominen, J. Raunamaa, T. Aalto, Terhi Ainiala, Helinä Uusitalo, E. Hyvönen   +6 more
semanticscholar   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

Linked Open Government Data: Still a Viable Option for Sharing and Integrating Public Data?

Future Internet
Linked Data (LD) principles, when applied to Open Government Data (OGD), aim to make government data accessible and interconnected, unlocking its full potential and facilitating widespread reuse.
Alfonso Quarati, Riccardo Albertoni
doaj   +1 more source

Linked Open Data Literacy for Librarians [PDF]

, 2014
Linked Data has become an important issue, not only for the process of building the web of data, but also for the mutual knowledge transfer between libraries and the web of data. Based on a study concerning Linked Open Data applications in libraries and the qualifications of future librarians involved in the development of such applications, we built a
Hügi, Jasmin, Schneider, René
openaire   +2 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source