Results 101 to 110 of about 40,024,399 (236)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Verified Algebra for Linked Data
, 2011 A foundation is investigated for the application of loosely structured data on the Web. This area is often referred to as Linked Data, due to the use of URIs in data to establish links.
Ross Horne +3 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A systematic literature review of open data quality in practice [PDF]
, 2016 Context: The main objective of open data initiatives is to make information freely available through easily accessible mechanisms and facilitate exploitation.
RASHID, MOHAMMAD RIFAT AHMMAD +1 more
core
RailGB: using open accessibility data to help people with disabilities
, 2012 With the fast growth of Linked Data, many datasets have been made available for public access. However, with an increased number of elderly and people with disabilities becoming technologically knowledgeable, it has been noted that few applications have ...
Newman, Russell +7 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Introduction to the Principles of Linked Open Data
, 2017 This lesson offers a brief and concise introduction to Linked Open Data (LOD). No prior knowledge is assumed. Readers should gain a clear understanding of the concepts behind linked open data, how it is used, and how it is created.
Jonathan Blaney
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Provenance in Linked Data Integration
, 2010 The open world of the (Semantic) Web is a global information space offering diverse materials of disparate qualities, and the opportunity to re-use, aggregate, and integrate these materials in novel ways. The advent of Linked Data brings the potential to
Gibbins, Nicholas +2 more
core +1 more source