Results 141 to 150 of about 5,195,087 (380)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A Research Agenda for Linked Closed Data
, 2011 While it is preferable that Linked Data is published without access or licence restrictions, there will always remain certain datasets which, perhaps due to financial considerations, cannot be published as Linked Open Data.
Black, Jennifer +4 more
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Generating Educational Assessment Items from Linked Open Data: The Case of DBpedia [PDF]
, 2012 Muriel Foulonneau
openalex +1 more source
Semantic Enrichment of a Multilingual Archive with Linked Open Data [PDF]
, 2017 This paper introduces MERCKX, a Multilingual Entity/Resource Combiner & Knowledge eXtractor. A case study involving the semantic enrichment of a multilingual archive is presented with the aim of assessing the relevance of natural language processing ...
De Wilde, Max, Hengchen, Simon
core
Representing Dataset Quality Metadata using Multi-Dimensional Views
, 2014 Data quality is commonly defined as fitness for use. The problem of identifying quality of data is faced by many data consumers. Data publishers often do not have the means to identify quality problems in their data.
Auer, Sören +2 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Practical Linked Data: Learning How to Create and Use Linked Data in the Real World [PDF]
, 2014 Want to learn more about linked data? This session is intended for anyone interested in learning more about linked data, whether they are new to the subject or more advanced. We will begin by describing what linked data is.
Becknell, Elissah +5 more
core +1 more source