Results 141 to 150 of about 40,024,399 (236)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Linked Timelines: Temporal Representation and Management in Linked Data

This paper addresses the issue of representing time entities (i.e. instants and intervals) as Linked Data, and how to exploit topological temporal relationships in order to increase the connectivity degree within Linked Data sets.
Millard, Ian, Correndo, Gianluca, Salvadores, Manuel, Shadbolt, Nigel   +3 more
core   +1 more source

The ChEMBL database as linked open data. [PDF]

J Cheminform, 2013
Willighagen EL, Waagmeester A, Spjuth O, Ansell P, Williams AJ, Tkachenko V, Hastings J, Chen B, Wild DJ.   +8 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Ontology-Based Querying with Bio2RDF's Linked Open Data. [PDF]

J Biomed Semantics, 2013
Callahan A, Cruz-Toledo J, Dumontier M.
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The EBI RDF platform: linked open data for the life sciences. [PDF]

Bioinformatics, 2014
Jupp S, Malone J, Bolleman J, Brandizi M, Davies M, Garcia L, Gaulton A, Gehant S, Laibe C, Redaschi N, Wimalaratne SM, Martin M, Le Novère N, Parkinson H, Birney E, Jenkinson AM.   +15 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Open data and charities

, 2012
Open data involves a paradigm shift in the way organisations manage their information and data: moving from a default of charities keeping data resources locked up in underused internal systems, to building a shared ‘Web of Data’.
Tiropanis, Thanassis, Hall, Wendy, O'Hara, Kieron, Shadbolt, Nigel, Davies, Tim   +4 more
core  

Design and development of a linked open data-based health information representation and visualization system: potentials and preliminary evaluation. [PDF]

JMIR Med Inform, 2014
Tilahun B, Kauppinen T, Keßler C, Fritz F.   +3 more
europepmc   +1 more source