Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Describing Research Data with CMDI—Challenges to Establish Contact with Linked Open Data
, 2020 Thorsten Trippel, Claus Zinn
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Development of an algorithm for ethnicity recording in cohorts from the UK Clinical Practice Research Datalink primary care and linked Hospital Episode Statistics databases. [PDF]
BMJ OpenShiekh SI, Williams R, Axson EL.
europepmc +1 more source
Search Engine for Halal Linked Open Data Using Entity Ranking Approach
, 2020 Ahmad Najib, Nur Aini Rakhmawati
openalex +2 more sources
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Optimising Paediatric Transition to Intensive Care for Adults (OPTICAL): study protocol for a mixed method study. [PDF]
BMJ OpenHuang Q +15 more
europepmc +1 more source
10 Women of Digital Humanities: An Analysis of Linked Open Data
, 2020 Lina Harper
openalex +2 more sources
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
An assessment of data quality and sociodemographic variation in health service utilisation of general practice, emergency department and admitted services in a New South Wales linked health data asset: a retrospective cohort study of Lumos. [PDF]
BMJ OpenBouckley T +11 more
europepmc +1 more source