Results 91 to 100 of about 331,196 (308)

Antibacterial and antibiofilm activity of N-aryl derivatives of benzimidazole, benzotriazole and their hybrids

Антибиотики и Химиотерапия
Background. The growing number of multidrug-resistant bacterial strains causing intractable infectious diseases has become one of the serious problems of the 21st century. Therefore, new drugs that act against resistant microorganisms are urgently needed.
R.  S. Begunov, D. O. Egorov, A. V. Chetvertakova, A. I. Khlopotinin, L. I. Savina, V. A. Vinogradova, A. A. Zubishina   +6 more
doaj   +1 more source

Degradable and Thermosensitive Microgels with Tannic Acid as the Sole Cross-Linker

, 2019
Poly­(N-isopropylacrylamide) (PNIPAM)–tannic acid (TA) microgels were successfully prepared via surfactant-free emulsion polymerization (SFEP) at 70 °C in aqueous solution using N-isopropylacrylamide (NIPAM) as the monomer and a natural polyphenol ...
Jingjing Nie, Jinqiao Xue (4217188), Zhijun Zhang (315079), Pengjia Yang (8039408), Jia Gao (221111), Weiming Ji, Shunni Dong (8039405), Jingjing Nie (1515709), Jinqiao Xue, Jia Gao, Weiming Ji (8039402), Shunni Dong, Zhijun Zhang, Binyang Du (1515715), Pengjia Yang, Binyang Du   +15 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Universal high-sensitivity CAR T-cell monitoring by targeting linker sequences

Frontiers in Immunology
IntroductionChimeric antigen receptor (CAR) T-cell therapy has become a standard-of-care in oncology, yet standardized monitoring of circulating CAR T cells remains a major challenge due to diverse CAR constructs and limited availability of detection ...
Nora Rebecca Schwingen, Lina Meretuk, Michael Aigner, Michael Aigner, Michael Aigner, Sascha Kretschmann, Sascha Kretschmann, Sascha Kretschmann, Julia Katharina Scholz, Franziska Gsottberger, Dennis Christoph Harrer, Janin Dingfelder, Janin Dingfelder, Gloria Lutzny-Geier, Gloria Lutzny-Geier, Gloria Lutzny-Geier, Soraya Kharboutli, Andreas Mackensen, Andreas Mackensen, Andreas Mackensen, Fabian Müller, Fabian Müller, Fabian Müller, Simon Völkl, Simon Völkl, Simon Völkl   +25 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Antibody-drug conjugates in cancer therapy: applications and future advances

Frontiers in Immunology
Antibody-Drug Conjugates (ADCs) represent an emerging cancer therapeutic strategy and are becoming increasingly significant in the field of public health.
Rou Long, Hanrong Zuo, Guiyang Tang, Chaohui Zhang, Xinru Yue, Jinsai Yang, Xinyu Luo, Yuqi Deng, Jieya Qiu, Jiale Li, Jianhong Zuo, Jianhong Zuo, Jianhong Zuo, Jianhong Zuo   +13 more
doaj   +1 more source

3D Bioprinting Using Cross-Linker-Free Silk–Gelatin Bioink for Cartilage Tissue Engineering

, 2019
Cartilage tissue is deprived of intrinsic self-regeneration capability; hence, its damage often progresses to a chronic condition which reduces the quality of life.
Yogendra Pratap Singh (2930130), Biman B. Mandal (2835641), Ashutosh Bandyopadhyay (7360538)   +2 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The abscence of the linker in double object constructions in Nuu

Studies in African Linguistics, 2004
The linker in Nluu appears before various types of nominal expressions, but not before the second object in a double object construction. Linkers in Khoisan languages such as +Hoan and Jul'hoansi do appear in this position. I will show that this property
Chris Collins
doaj   +1 more source