Results 81 to 90 of about 331,196 (308)

Antibody–drug conjugate: a newly developed biological missile for tumor treatment

Frontiers in Oncology
Antibody–drug conjugates (ADCs) represent one of the most advanced drug configurations under current research, primarily composed of a monoclonal antibody (mAb), a highly potent cytotoxic payload, and a linker that connects the drug to the antibody.
Zhuoran Tang, Yanchun Xie, Yanping Zeng
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Antibody–Drug Conjugates (ADCs): A Review of Structural Design, Technological Evolution, and Future Perspectives

Molecules
Antibody–drug conjugates (ADCs) have become an important class of targeted anticancer therapeutics by integrating the tumor selectivity of monoclonal antibodies with the potent cytotoxicity of small-molecule payloads through rational linker design.
Guiying Wu, Zhenhai Yuan, Ming Chen, Xuan Tang, Fang Wang, Daizhou Zhang   +5 more
doaj   +1 more source

A special case of long distance agreement in Marathi

Glossa, 2020
This paper discusses an unexplored case of long distance agreement (LDA) in Marathi in which agreement takes place across an embedded subjunctive clause. In this construction, three distinct heads- an embedded verb, a matrix verb and what appears to be a
Renuka Ozarkar
doaj   +2 more sources

Integrated Workflow for Structural Proteomics Studies Based on Cross-Linking/Mass Spectrometry with an MS/MS Cleavable Cross-Linker

, 2016
Cross-linking combined with mass spectrometry (MS) has evolved as an alternative strategy in structural biology for characterizing three-dimensional structures of protein assemblies and for mapping protein–protein interactions.
Christian Arlt (2892365), Christoph Hage (2892368), Christian H. Ihling (407284), Andrea Sinz (407286), Michael Götze (2892371), Mathias Schäfer (1694968)   +5 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Antibody-drug conjugates in cancer therapy: current advances and prospects for breakthroughs

Frontiers in Cell and Developmental Biology
Antibody-drug conjugates (ADCs), often referred to as “intelligent biological missiles,” have garnered significant attention in the rapidly evolving landscape of cancer therapy. ADCs represent a sophisticated approach by integrating monoclonal antibodies
Dan Wu, Dan Wu, Dan Wu, Kaixuan Yang, Kaixuan Yang, Runjia He, Rutie Yin, Rutie Yin, Lin Shui, Lin Shui   +9 more
doaj   +1 more source

Albumin-Binding PSMA Radioligands: Impact of Minimal Structural Changes on the Tissue Distribution Profile

Molecules, 2020
The concept of using ibuprofen as an albumin-binding entity was recently demonstrated by the development of [177Lu]Lu-Ibu-PSMA-01. In the present study, we designed a novel ibuprofen-containing radioligand (Ibu-PSMA-02) with subtle structural changes ...
Luisa M. Deberle, Viviane J. Tschan, Francesca Borgna, Fan Sozzi-Guo, Peter Bernhardt, Roger Schibli, Cristina Müller   +6 more
doaj   +1 more source

Highly Deformable Nano-Cross-Linker-Bridged Nanocomposite Hydrogels for Water Management of Oil Recovery

, 2018
Conventional poly­(acrylamide) (PAM)-based hydrogels suffered from mechanical instability during water flooding, which markedly reduced their performance for water management and oil recovery.
Bai, Baojun, Lizhu Wang, Lizhu Wang (1553689), Baojun Bai, Baojun Bai (748172), Geng, Jiaming, Wang, Lizhu, Jiaming Geng (4873150), Jiaming Geng   +8 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source