Results 61 to 70 of about 331,196 (308)
Pharmaceuticals, 2021 Combining the selective targeting of tumor cells through antigen-directed recognition and potent cell-killing by cytotoxic payloads, antibody-drug conjugates (ADCs) have emerged in recent years as an efficient therapeutic approach for the treatment of ...
Vesela Kostova +3 more
doaj +1 more source
Enhancing Structural Control in Covalent Organic Frameworks through Steric Interaction-Driven Linker Design [PDF]
, 2023 Covalent Organic Frameworks (COFs) exhibiting kagome (kgm) structures are promising crystalline porous materials with two distinct pores. However, the challenge arises from the potential formation of the polymorphic square-lattice (sql) structure, which ...
Panagiotis, Kastritis +5 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Soft Mode Metal-Linker Dynamics in Carboxylate MOFs [PDF]
, 2020 Through comprehensive analysis of carboxylate-based metal-organic frameworks (MOFs), we present general evidence for dynamic metal-linker bonding that challenges the common perception of MOF structures being static.
Michael E., Kellman +5 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2019 Zeolitic imidazolate frameworks (ZIFs) have gained much interest due to their potentials in gas separations. A hybrid approach by mixing metals and/or linkers has been recently investigated to fine-tune the ZIF framework porosity and surface properties ...
Febrian Hillman +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy
Molecules, 2017 Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal antibodies through appropriate linkers.
Hao Chen +4 more
doaj +1 more source
Intuitionistic Euler-Venn Diagrams [PDF]
, 2020 We present an intuitionistic interpretation of Euler-Venn diagrams with respect to Heyting algebras. In contrast to classical Euler-Venn diagrams, we treat shaded and missing zones differently, to have diagrammatic representations of conjunction ...
Linker, Sven, Linker, S, Sven Linker
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source