Results 211 to 220 of about 4,236,805 (394)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. [PDF]

Pharmaceutics
Jaime-Garza M, Waight A, Hudlikar M, Eddins MJ, Rasti ES, Zaragoza JPT, Fayadat-Dilman L, Chrencik JE, Gabelli SB, Chen YT, Noland CL.   +10 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Synergizing network topology and solvent compatibility for gels with hyperelasticity and omniadhesion. [PDF]

Sci Adv
Xue Q, He X, Lei J, Hong W, Yang C.
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Antibody-Drug Conjugates in Hematological Malignancies: Current Landscape and Future Perspectives. [PDF]

Int J Mol Sci
Montalbano MC, Micillo M, Deaglio S, Vaisitti T.   +3 more
europepmc   +1 more source

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Molecular Cancer Therapeutics, 2016
M. Dorywalska, R. Dushin, L. Moine, Santiago E Farias, Dahui Zhou, T. Navaratnam, Victor Lui, Adela Hasa-Moreno, M. Casas, Thomas-Toan Tran, K. Delaria, Shu-Hui Liu, D. Foletti, C. J. O’Donnell, J. Pons, D. Shelton, A. Rajpal, P. Strop   +17 more
semanticscholar   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Structural basis for heme binding by the Shr protein from Streptococcus pyogenes. [PDF]

J Biol Chem
Seki K, Senoo A, Nagatoishi S, Yanaka S, Nakakido M, Tsumoto K, Caaveiro JMM.   +6 more
europepmc   +1 more source

Sok link = Internet? A kapcsolati tőke szerepe a számítógép és Internet-, valamint a számítógépes tudás terjedésében a kaposvári kistérségben, kérdőíves adatfelvétel és résztvevő megfigyelés alapján [PDF]

, 2003
Eliza Eranus, László Letenyei, Viktória Siklós   +2 more
openalex