Results 81 to 90 of about 233,603 (255)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A variational framework for residual-based adaptivity in neural PDE solvers and operator learning

npj Artificial Intelligence
Residual-based adaptive strategies are widely used in scientific machine learning yet remain largely heuristic. We introduce a variational framework that formalizes these methods through convex transformations of the residual, where different ...
Juan Diego Toscano, Daniel T. Chen, Vivek Ooomen, Jérôme Darbon, George Em Karniadakis   +4 more
doaj   +1 more source

Domain estimation under informative linkage

Statistical Theory and Related Fields, 2019
A standard assumption when modelling linked sample data is that the stochastic properties of the linking process and process underpinning the population values of the response variable are independent of one another.
Ray Chambers, Nicola Salvati, Enrico Fabrizi, Andrea Diniz da Silva   +3 more
doaj   +1 more source

Placing Multiple Tests on a Common Scale Using a Post-test Anchor Design: Effects of Item Position and Order on the Stability of Parameter Estimates

Frontiers in Applied Mathematics and Statistics, 2018
When there is an interest in tracking longitudinal trends of student educational achievement using standardized tests, the most common linking approach generally involves the inclusion of a common set of items across adjacent test administrations ...
Davide Marengo, Renato Miceli, Rosalba Rosato, Michele Settanni   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of particle tracking codes for dispersing particles in porous media

Scientific Reports
Particle tracking (PT) is a popular technique in microscopy, microfluidics and colloidal transport studies, where image analysis is used to reconstruct trajectories from bright spots in a video.
Marc Berghouse, Filippo Miele, Lazaro J. Perez, Ankur Deep Bordoloi, Verónica L. Morales, Rishi Parashar   +5 more
doaj   +1 more source

Linking household surveys and health facility assessments to estimate intervention coverage for the Lives Saved Tool (LiST)

BMC Public Health, 2017
Background Calls have been made for improved measurement of coverage for maternal, newborn and child health interventions. Recently, methods linking household and health facility surveys have been used to improve estimation of intervention coverage ...
Mufaro Kanyangarara, Victoria B. Chou
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Error-driven upregulation of memory representations

Communications Psychology
Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation.
Alexander Weuthen, Hans Kirschner, Markus Ullsperger   +2 more
doaj   +1 more source