Results 131 to 140 of about 4,794 (165)

Significant enhancement of lignan accumulation in hairy root cultures of Linum album using biotic elicitors

Acta Physiologiae Plantarum, 2014
Linum album has been shown to accumulate some lignans with antiviral and anticancer properties such as podophyllotoxin (PTOX) and 6-methoxy podophyllotoxin (MPTOX). In this research, we examined the effects of fungal elicitors on the production of lignans in L. album hairy root cultures. The biosynthesis of lignans was differentially affected by fungal
Sedigheh Esmaeilzadeh Bahabadi, Mozafar Sharifi, Najme Ahmadian Chashmi, Jun Murata, Honoo Satake   +4 more
openaire   +3 more sources

In vitro polyploidy induction: changes in morphology, podophyllotoxin biosynthesis, and expression of the related genes in Linum album (Linaceae)

Planta, 2017
Induction of tetraploidy was performed and podophyllotoxin production increased by upregulating the expression level and enzyme activity of genes related to its biosynthesis in tetraploid compared to diploid Linum album. Linum album is a valuable medicinal plant that produces antiviral and anticancer compounds including podophyllotoxin (PTOX).
Neda, Javadian, Ghasem, Karimzadeh, Mohsen, Sharifi, Ahmad, Moieni, Mehrdad, Behmanesh   +4 more
openaire   +4 more sources

Enhanced production of podophyllotoxins by co-culture of transformed Linum album cells with plant growth-promoting fungi

Pure and Applied Chemistry, 2010
To investigate the plant growth-promoting effect and stimulation of lignan biosynthesis, the effect of culture filtrates/live co-culture of two arbuscular mycorrhizae-like fungi, Piriformospora indica and Sebacina vermifera, on growth of Linum album cells and on production of podophyllotoxin (PT) and 6-methoxypodophyllotoxin (6-MPT) was studied.
Ashish Baldi, Sunita Farkya, Abhishek Jain, Nishant Gupta, Rahul Mehra, Vatsala Datta, Ashok Kumar Srivastava, Virendra Swarup Bisaria   +7 more
openaire   +3 more sources

Podophyllotoxin from suspension culture of Linum album

Natural Product Research, 2008
Callus and suspension cultures of Linum album as an Iranian species for synthesis of aryltetralin lactone were used. After cultivation period; we can isolate and characterize podophyllotoxin as glycosides compounds. Maximal product yield is 0.5% of the dry weight in dark grown cultures.
Soheila, Sedaghat, Elham, Ezatzadeh, A Wilhelm, Alfermann   +2 more
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Molecular analysis of somaclonal variation in Linum usitatissimum and L. album

Plant Gene, 2020
Abstract Flax plant (Linum usitatissimum) is an important oilseed crop, with an annual world production of around three million tons. Flax is a crop with a rather low genetic variability and agriculturally important traits. Biotechnology and somaclonal variation is a potential way of inducing genetic variation in Linum.
Zahra Noormohammadi, Hadi Habibollahi, Farah Farahani, Masoud Sheidai   +3 more
openaire   +1 more source

Pinoresinol–lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum

Phytochemistry, 2005
Recently it was found that cell cultures and plants of Linum species contain lignans of various chemical structures. The stereochemistry of these compounds differ among species. Cell cultures of L. album accumulate (-)-podophyllotoxin together with pure (-)-secoisolariciresinol.
Cosima B I, von Heimendahl, Katrin M, Schäfer, Patrik, Eklund, Rainer, Sjöholm, Thomas J, Schmidt, Elisabeth, Fuss   +5 more
openaire   +2 more sources

Metabolic and Physiological Changes Induced by Exogenous Phenylalanine in Linum album Cells

Journal of Plant Growth Regulation
Mostafa Sagharyan, Mohsen Sharifi
openaire   +3 more sources

Improved podophyllotoxin production by transformed cultures of Linum album

Biotechnology Journal, 2008
AbstractVarious cell and hairy root cultures of L. album were developed and analyzed for podophyllotoxin content. Transformed callus and hairy root cultures developed from infection of stem portions of in vitro‐germinated L. album plant with Agrobacterium rhizogenes NCIM 5140 strain were selected on the basis of high podophyllotoxin content and growth.
Ashish, Baldi, Ashok K, Srivastava, Virendra S, Bisaria   +2 more
openaire   +2 more sources

Infra-specific genetic and morphological diversity in Linum album (Linaceae)

Biologia, 2013
The genus Linum L. (Lineacea) has over 15 species, subspecies or ecotypes in Iran. These species show extensive geographical distribution and form many local populations throughout the country. Linum album is herbaceous medicinal plant containing important lignans such as podophyllotoxin (PTOX) and 6-methoxy podophyllotoxin (MPTOX), which have ...
Masoud Sheidai, Somayeh Ziaee, Fatemeh Farahani, Seyed-Mehdi Talebi, Zahra Noormohammadi, Yeganeh Hasheminejad-Ahangarani Farahani   +5 more
openaire   +1 more source

Comparing aryltetralin lignan accumulation patterns in four biotechnological systems of Linum album

Journal of Plant Physiology, 2018
Linum album is a herbaceous plant with medical interest due to its content of podophyllotoxin (PTOX), an aryltetralin lignan with cytotoxic activity. Previous studies in our laboratory showed that cell suspension cultures of L. album produced more PTOX than methoxypodophyllotoxin (6-MPTOX), both lignans being formed from the same precursor after ...
Liliana Lalaleo, Rubén Alcazar, Javier Palazon, Elisabeth Moyano, Rosa M. Cusido, Mercedes Bonfill   +5 more
openaire   +2 more sources