Results 141 to 150 of about 4,794 (165)

Potential Anticancer Agents II: Antitumor and Cytotoxic Lignans from Linum Album (Linaceae)

Journal of Pharmaceutical Sciences, 1975
A phytochemical study of Linum album (Linaceae), guided by bioassay with the 9KB cell culture, resulted in the isolation of podophyllotoxin and a new lignan, 3'-demethylpodophyllotoxin; alpha-and beta-peltatins were identified by comparative TLC.
S G, Weiss, M, Tin-Wa, R E, Perdue, N R, Farnsworth   +3 more
openaire   +2 more sources

Accumulation of podophyllotoxin and related lignans in cell suspension cultures of linum album

Phytochemistry, 1998
Cell suspension cultures of Linum album were established, which were able to synthesize and accumulate lignans. Podophyllotoxin and 5-methoxypodophyllotoxin were the main products and were present as glycosides, together with small amounts of deoxypodophyllotoxin, 5′-demethoxy-5-methoxypodophyllotoxin, lariciresinol, pinoresinol, matairesinol, α- and β-
Smollny, T., Wichers, H., Kalenberg, S., Shahsavari, A., Petersen, M., Alfermann, A.W.   +5 more
openaire   +2 more sources

Hydrogen sulfide directs metabolic flux towards the lignan biosynthesis in Linum album hairy roots

Plant Physiology and Biochemistry, 2019
Hydrogen sulfide (H2S) has been recently found as an important signaling molecule especially in root system architecture of plants. The regulation of root formation through H2S has been reported in previous works; while the profiling of metabolites in response to H2S is not clearly discussed. To this end, different concentrations of sodium hydrosulfide
Safieh Fakhari, Mohsen Sharifi, Roberto De Michele, Faezeh Ghanati, Naser Safaie, Ehsan Sadeghnezhad   +5 more
openaire   +3 more sources

The effect of light on gene expression and podophyllotoxin biosynthesis in Linum album cell culture

Plant Physiology and Biochemistry, 2012
Podophyllotoxin (PTOX) is a naturally occurring phenolic compound isolated as an active anti-tumor agent. The stimulatory influence of light on the formation of phenolic compounds has been reported, but the molecular mechanism underlying the effect of light on the expression of genes involved in phenolic biosynthesis, especially of lignans, is still ...
Morteza, Yousefzadi, Mozafar, Sharifi, Mehrdad, Behmanesh, Alireza, Ghasempour, Elisabeth, Moyano, Javier, Palazon   +5 more
openaire   +2 more sources

Exogenous Hormones Affecting Morphology and Biosynthetic Potential of Hairy Root Line (LYR2i) of Linum album

Journal of Bioscience and Bioengineering, 2008
A hairy root line of Linum album LYR2i was obtained via the genetic transformation of a cotyledon segment of the plant by cocultivating it with Agrobacterium rhizogenes and culturing it in hormone-free B5 Gamborg liquid medium. Characteristic changes in root morphology associated with variations in biosynthetic capabilities were achieved by adding ...
Sunita, Farkya, Virendra Swarup, Bisaria
openaire   +2 more sources

Lignan enhancement in hairy root cultures of Linum album using coniferaldehyde and methylenedioxycinnamic acid

Preparative Biochemistry and Biotechnology, 2015
Feeding experiments with hairy root cultures of Linum album have established that the extracellular coniferaldehyde is a good precursor for production of two lignans: lariciresinol (LARI) and pinoresinol (PINO). The accumulation of the LARI, PINO, and podophyllotoxin (PTOX) in hairy roots were enhanced about 14.8-, 8.7-, and 1.5-fold (107.61, 8.7 and 6.
Najmeh, Ahmadian Chashmi, Mohsen, Sharifi, Mehrdad, Behmanesh   +2 more
openaire   +2 more sources

Methyl jasmonate redirects the dynamics of carbohydrates and amino acids toward the lignans accumulation in Linum album cells

Plant Physiology and Biochemistry, 2023
Linum album accumulates lignans e.g., podophyllotoxin (PTOX) and 6-methoxy podophyllotoxin (6MPTOX). This study was aimed to figure out how different concentrations of MeJA (0, 50, 100, 150, and 200 μM) by affecting on free sugars and amino acids contents induce lignans accumulation in L. album cells.
Mostafa, Sagharyan, Mohsen, Sharifi, Elaheh, Samari   +2 more
openaire   +2 more sources

Effect of Aeration on Production of Anticancer Lignans by Cell Suspension Cultures of Linum album

Applied Biochemistry and Biotechnology, 2008
The effects of aeration within the range of 0.2-0.5 vvm on transformed and high yielding cell cultures of Linum album were investigated in a 5-L stirred tank bioreactor equipped with low shear Setric impeller. The kinetics of cell growth, substrate utilization, and production of lignans, namely, podophyllotoxin and 6-methoxypodophyllotoxin, were ...
Ashish, Baldi, Ashok K, Srivastava, Virendra S, Bisaria   +2 more
openaire   +2 more sources

Quantification of Aryltetralin Lignans in Linum album Organs and In Vitro Cultures

Iranian Journal of Pharmaceutical Sciences
Aprocedure was developed for rapid in vitro germination of Linum album seeds by scarification and exposing to gibberellic acid (GA3) and kinetin (Kn). Concentrations of podophyllotoxin (PTOX) and related aryltetralin lignans α-peltatin, β-peltatin, 5’-demethoxy-6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin (MPTOX) in L. album fresh plant organs
Mohagheghzadeh, Abdolali, Hemmati, Shiva, Alfermann, A. Wilhelm   +2 more
openaire   +1 more source

Co-Culture of Linum album Cells and Piriformospora indica for Improved Production of Phytopharmaceuticals

2009
Inability of arbuscular mycorrhizal fungi to grow in pure cultures without living host roots is one of the most challenging hurdles to studying their symbiotic relationship with plants and their effect on cell growth and secondary metabolite production.
A. Baldi, A. Jain, N. Gupta, A. K. Srivastava, V. S. Bisaria   +4 more
openaire   +1 more source