Results 101 to 110 of about 26,289 (283)

NIR II‐Guided Photoactivatable Silencing Polyplex Boosts Cancer Immunotherapy

Exploration, EarlyView.
Due to limitation of penetration therapy with first and second‐generation photodynamic therapy (PDT) photosensitizers, an NIR II‐guided photoactivatable complex was proposed via the self‐assembly of the photosensitive polymer PTSQ and the electrostatic adsorption of siPD‐L1 to enhance cancer immunotherapy.
Yuquan Zhang, Jie Wang, Tian Zhang, Dongsheng Tang, Haiyin Yang, Shuai Guo, Yuchuan Fan, Caixia Sun, Haihua Xiao, Yuanyu Huang, Yuhua Weng   +10 more
wiley   +1 more source

Deficiency in infiltration of CD8/CD3 positive lymphocytes and macrophages plays a role in lip carcinogenesis: an immunohistochemical study

Brazilian Journal of Otorhinolaryngology
Objective: To evaluate the immunoexpression profile for CD8, CD3, CD20 and CD68 in the process and carcinogenesis of Carcinoma of the vermilion lip. Methods: Average cell count with positive expression for CD3, CD8, CD20 and CD68.
Iana Aragão Magalhães, Gabriella Alves Juliao Costa, Marcela Maria Fontes Borges, Anna Clara Aragão Matos Carlos, Karine Cestaro Mesquita, Larissa Mont´Alverne de Arruda, Maria do Perpétuo Socorro Saldanha Cunha, Fabrício Bitu Sousa, Paulo Goberlânio de Barros Silva   +8 more
doaj   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Assessing Head and Neck Cancer‐Related Lymphoedema Using Indocyanine Green Lymphography—A Pilot Study

Head &Neck, EarlyView.
ABSTRACT Background Head and neck cancer treatments can cause head and neck lymphoedema (HNL), impacting quality of life (QoL). This study examined lymphatic drainage changes in HNL using Indocyanine Green Lymphography (ICG‐L) and assessed QoL, physical, and functional outcomes.
Katrina Gaitatzis, Belinda Thompson, Hiroo Suami, Fiona Tisdall Blake, Asha Heydon‐White, Puma Sundaresan, Dion Forstner, Louise Koelmeyer   +7 more
wiley   +1 more source

Application of a Saliva‐Based Liquid Biopsy for the Detection of HPV in Patients With Oral Cavity Squamous Cell Carcinoma (OCSCC)

Head &Neck, EarlyView.
ABSTRACT Background Human papilloma virus (HPV) is a DNA virus capable of infecting mucous membranes. In most cases, the infection is cleared by the immune system, but a prolonged exposure to HPV can progress to cancer. 40%–60% of head and neck squamous cell carcinomas (HNSCC) are linked to HPV, which is considered a risk factor especially among young ...
Michela Bulfoni, Alessandro Tel, Beatrice Krpan, Barbara Marcon, Maria De Martino, Giorgia Vesca, Cinzia Lombardo, Stefania Marzinotto, Emanuele Nencioni, Salvatore Sembronio, Corrado Pipan, Massimo Robiony, Francesco Curcio   +12 more
wiley   +1 more source

Liquid Biopsies in Head and Neck Cancers: Recent Developments Across Biofluids, Analytes, and Molecular Features

Head &Neck, EarlyView.
ABSTRACT Background Head and neck cancers (HNCs) are too often diagnosed at advanced stages when outcomes are poor. Additionally, robust tools for the early detection of recurrence remain elusive. These gaps drive interest in so‐called liquid biopsy approaches for HNC detection, prognostication, and surveillance.
Patricia J. Brooks, Scott V. Bratman
wiley   +1 more source

Safety and Efficacy Findings From a Phase Ib/II Study of ASP‐1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing. Methods This phase Ib/II open‐label study evaluated ASP‐1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD‐L1 ...
David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne M. Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater   +17 more
wiley   +1 more source

The risk of basal and squamous cell carcinomas of the skin cancer incidence and external radiation in the updated National Registry for radiation workers cohort in the UK

International Journal of Cancer, EarlyView.
What's New? While ultraviolet radiation from the sun is the main risk factor for non‐melanoma skin cancer (NMSC), additional factors contribute to NMSC development. The present study examined the impact of occupational radiation exposure on NMSC risk among radiation workers in the United Kingdom.
Nezahat Hunter, Richard Haylock
wiley   +1 more source

Body height and the excess cancer risk in men

International Journal of Cancer, EarlyView.
What's New? In cancers that affect both sexes, men usually have a higher risk than women. While this is often attributed to behavioral factors, such as exposure to environmental carcinogens, there may be an intrinsic biological mechanism involved. Tall stature has been associated with increased cancer risk.
Cecilia Radkiewicz, Gustaf Edgren, Arvid Sjölander, Emelie Benyi, Mats Lambe, Paul W. Dickman, Lars Sävendahl   +6 more
wiley   +1 more source

Gingival plasma cell granuloma

Indian Journal of Dental Research, 2010
Plasma cell granuloma is a rare reactive lesion composed of polyclonal plasma cells. It manifests primarily in the lungs, but may occur in various other anatomic locations like the oral cavity.
Phadnaik Mangesh, Attar Nilofar
doaj