Results 231 to 240 of about 1,939,990 (302)

TMEM135 deficiency prevents intestinal lipid accumulation by coordinating lipid uptake and oxidation through ELOVL6-mediated PPARα activation. [PDF]

Exp Mol Med
Kim H, Park C, Wei X, Chhetri A, Manandhar L, Seo J, Park Y, Lee SW, Park R.   +8 more
europepmc   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

FABP3 Aggravates Cerebral Ischemia-Reperfusion Injury by Promoting Mitochondrial Lipid Accumulation and Enhancing BAX-Dependent Apoptosis. [PDF]

Cells
Zheng Y, Luo A, Fukunaga K, Liu Q, Guo Q.   +4 more
europepmc   +1 more source

Quantification of Phosphorylated Tau Protein in Alzheimer's Disease Patients’ Fluids With Electrolyte‐Gated Organic Transistor Biosensors

Advanced Healthcare Materials, EarlyView.
Dementia syndrome affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. We report the detection of the specific biomarker for AD, p‐tau‐181, from physiological to pathological concentrations in cerebrospinal fluid using an electrolyte‐gated organic transistor biosensor.
Marcello Berto, Pamela A. Manco Urbina, Alessandro Paradisi, Matteo Sensi, Najara Iacovino, Chiara Carbone, Roberta Bedin, Marcello Pinti, Fabio Biscarini, Giovanna Zamboni, Carlo A. Bortolotti   +10 more
wiley   +1 more source

Association between lipid accumulation product and visceral adiposity index and rheumatoid arthritis: NHANES 1999-2018. [PDF]

Lipids Health Dis
Xu J, Xu Y, Wei F.
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

BIX02189 Suppresses Adipogenesis and Lipid Accumulation Through Inhibition of MEK5-STAT3/STAT5 Signaling and Activation of AMPK in Adipocytes and Zebrafish. [PDF]

Int J Mol Sci
Perumal NL, Hussain M, Son DG, Stephens JM, Park GY, Jang BC.   +5 more
europepmc   +1 more source

Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo

Advanced Healthcare Materials, EarlyView.
Silicone breast implants are presented as a model system for understanding polymer permeation in vivo. Rather than representing material failure, “gel bleed” emerges from solution–diffusion transport‐mediated. By integrating polymer architecture, physicochemical transport, and biointerfacial processes, this review provides a unified framework that ...
D. Bouyer, H. Mutlu, C. Charmette, E. Randrianaridera, Z. Adaidi, R. Hedna, L. Pieuchot, I. Pluvy, K. Anselme, N. Couturier, J. P. Mericq, A. Ponche, I. Brigaud   +12 more
wiley   +1 more source

The Role of ATG8 in Promoting Lipid Accumulation in the Oleaginous Fungus <i>Mucor circinelloides</i> During Nitrogen Limitation. [PDF]

J Fungi (Basel)
Li H, Yuan H, Iqbal B, Wang T, Wang Z, Zhang H.   +5 more
europepmc   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source