Results 301 to 310 of about 229,223 (348)
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2015
Water is crucial to the structure and function of biological membranes. In fact, the membrane's basic structural unit, i.e. the lipid bilayer, is self-assembled and stabilized by the so-called hydrophobic effect, whereby lipid molecules unable to hydrogen bond with water aggregate in order to prevent their hydrophobic portions from being exposed to ...
Jonathan D, Nickels, John, Katsaras
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Water is crucial to the structure and function of biological membranes. In fact, the membrane's basic structural unit, i.e. the lipid bilayer, is self-assembled and stabilized by the so-called hydrophobic effect, whereby lipid molecules unable to hydrogen bond with water aggregate in order to prevent their hydrophobic portions from being exposed to ...
Jonathan D, Nickels, John, Katsaras
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Texture of Lipid Bilayer Domains
Journal of the American Chemical Society, 2009We investigate the texture of gel (g) domains in binary lipid membranes composed of the phospholipids DPPC and DOPC. Lateral organization of lipid bilayer membranes is a topic of fundamental and biological importance. Whereas questions related to size and composition of fluid membrane domain are well studied, the possibility of texture in gel domains ...
Jensen, Uffe Bernchou +5 more
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Paclitaxel Partitioning into Lipid Bilayers
Journal of Pharmaceutical Sciences, 1996Paclitaxel (taxol) is diterpenoid anticancer drug with a new mechanism of cytostatic action. It is under investigation in clinical trials for treatment of various types of human cancer. A major difficulty in developing paclitaxel as a chemotherapeutic agent in its poor water solubility.
Wenk, M. R. +3 more
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Berichte der Bunsengesellschaft für physikalische Chemie, 1978
AbstractThin lipid membranes formed across an aperture in a teflon foil are frequently used as model systems to simulate the hydrophobic diffusion barrier of biological membranes. These membranes have a thickness of about twice the length of a lipid molecule (bilayer membranes) and are prepared either by a spontaneous transition of a thick lamella made
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AbstractThin lipid membranes formed across an aperture in a teflon foil are frequently used as model systems to simulate the hydrophobic diffusion barrier of biological membranes. These membranes have a thickness of about twice the length of a lipid molecule (bilayer membranes) and are prepared either by a spontaneous transition of a thick lamella made
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Photoelectrospectrometry of bilayer lipid membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1980These different bilayer lipid membrane systems were studied under visible and ultraviolet illumination. The first system consisted of a bilayer lipid membrane formed with a mixture of phospholipids and cholesterol, to one side of which purple membrane fragments from Halobacterium halobium were added.
J R, Lopez, H T, Tien
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Lipid-polypeptide interactions in bilayer lipid membranes
The Journal of Membrane Biology, 1972The modifications of the electrical properties of bilayer lipid membranes (BLM) composed of cholesterol and an ionic surfactant upon interaction with charged polypeptides were studied. The addition of 10(-8) M polylysine (Ps(+)) to one side of anionic cholesterol dodecylphosphate BLM increases the specific membrane conductance over 1000-fold (from 10 ...
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Multiscale modeling of lipids and lipid bilayers
European Biophysics Journal, 2005A multiscale modeling approach is applied for simulations of lipids and lipid assemblies on mesoscale. First, molecular dynamics simulation of initially disordered system of lipid molecules in water within all-atomic model was carried out. On the next stage, structural data obtained from the molecular dynamics (MD) simulation were used to build a ...
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Lipid Bilayer Electropermeabilization
2004In the majority of cells, under normal physiological conditions, there exists a transmembrane potential difference of about several tens of millivolts. This means that the electric field in biomembranes is rather high, approximately 105 V/cm. With a further increase in the electric field, biomembranes undergo changes that lead to a drastic (by 5-7 ...
Yuri A. Chizmadzhev +2 more
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Proton permeation of lipid bilayers
Journal of Bioenergetics and Biomembranes, 1987Proton permeation of the lipid bilayer barrier has two unique features. First, permeability coefficients measured at neutral pH ranges are six to seven orders of magnitude greater than expected from knowledge of other monovalent cations. Second, proton conductance across planar lipid bilayers varies at most by a factor of 10 when pH is varied from near
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