Results 161 to 170 of about 2,639,820 (355)

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, EarlyView.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source

Lipid Metabolism in Human Skin

, 1966
S.L. Hsia, M.A. Dreize, Méndez Márquez
openalex   +1 more source

STUDIES ON LIPID METABOLISM IN THE SMALL INTESTINE WITH OBSERVATIONS ON THE ROLE OF BILE SALTS*† [PDF]

, 1960
Anthony M. Dawson, Kurt J. Isselbacher
openalex   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B

Journal of Lipid Research, 1996
In order to investigate causes of variability in low density lipoprotein (LDL) particle size, we have assessed LDL composition in plasma from 66 subjects, each with a single LDL band, by 2-16% gradient gel electrophoresis, with a total of eight discrete ...
J R McNamara, D M Small, Z Li, E J Schaefer   +3 more
doaj  

METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS* [PDF]

, 1963
Paul J. Nestel, Richard J. Havel, A. Bezman   +2 more
openalex   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement

Journal of Lipid Research, 2002
Due to conflicting reports concerning the relationship between phospholipid transfer protein (PLTP) activity and mass in plasma, the protein concentration and activity of PLTP were assessed in fractions isolated by fast protein liquid chromatography from
Susan J. Murdoch, Gertrud Wolfbauer, Hal Kennedy, Santica M. Marcovina, Molly C. Carr, John J. Albers   +5 more
doaj  

EXTRATHYROIDAL ACTIONS OF PITUITARY THYROTROPIN: EFFECTS ON THE CARBOHYDRATE, LIPID AND RESPIRATORY METABOLISM OF RAT ADIPOSE TISSUE* [PDF]

, 1961
Norbert Freinkel
openalex   +1 more source