Results 181 to 190 of about 1,222,168 (350)

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Perilipins: key targets for regulating lipid metabolism and alleviating abnormal lipid metabolism through exercise. [PDF]

Diabetol Metab Syndr
Niu YJ, Liu JJ, Zhang JH, Lu SQ, Wang K, Zhu Z, Cao ZB.   +6 more
europepmc   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

MDSCs in Breast Cancer: Metastasis, Lipid Metabolism, and Therapeutics. [PDF]

Mol Cancer Res
Kim U, Chakrabarti R.
europepmc   +1 more source

Altered dynamics of lipid metabolism in muscle cells from patients with idiopathic inflammatory myopathy is ameliorated by 6 months of training [PDF]

, 2020
Michal Nemec, Lucia Vernerová, Nikoleta Alchus Laiferová, Mária Balážová, Martina Vokurková, Tímea Kurdiová, Sabína Oreská, Kateřina Kubínová, Martin Klein, Maja Špiritović, Michal Tomčík, Jiří Vencovský, Jozef Ukropec, Barbara Ukropcová   +13 more
openalex   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer's Disease. [PDF]

Cell Mol Neurobiol
Shen Y, Wang X, Liu X, Wang G, Hou X, Zhou X.   +5 more
europepmc   +1 more source

Impact of the Extracellular Vesicles Derived From Trypanosoma cruzi: A Paradox in Host Response and Lipid Metabolism Modulation

, 2021
Heloísa D’Ávila, Núbia Pereira de Souza, Ana Luíza da Silva Albertoni, Laíris Cunha Campos, Pollianne Garbero Rampinelli, José R. Corrêa, Patrícia E. de Almeida   +6 more
openalex   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Mitochondrial and lipid metabolism rewiring during HEV infection. [PDF]

Cell Mol Life Sci
Glaziou Q, Chen Q, Gouilly J, Wu M, Duhamel M, Salzet M, Izopet J, Al Daccak R, El Costa H, Jabrane-Ferrat N.   +9 more
europepmc   +1 more source