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Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids [PDF]

International Journal of Pharmaceutics: X
Lipid nanoparticles (LNPs) have emerged as promising carriers for delivering therapeutic agents, including mRNA-based immunotherapies, in various biomedical applications.
Alanood S. Alfutaimani, Nouf K. Alharbi, Amirah S. Alahmari, Almaha A. Alqabbani, Abdulaziz M. Aldayel   +4 more
doaj   +5 more sources

Role of size, surface charge, and PEGylated lipids of lipid nanoparticles (LNPs) on intramuscular delivery of mRNA [PDF]

Journal of Nanobiotechnology
Lipid nanoparticles (LNPs) are currently the most commonly used non-viral gene delivery system. Their physiochemical attributes, encompassing size, charge and surface modifications, significantly affect their behaviors both in vivo and in vitro ...
Weiwen Kong, Yuning Wei, Zirong Dong, Wenjuan Liu, Jiaxin Zhao, Yan Huang, Jinlong Yang, Wei Wu, Haisheng He, Jianping Qi   +9 more
doaj   +5 more sources

siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases. [PDF]

Pharmaceutics, 2022
RNAi (RNA interference)-based technology is emerging as a versatile tool which has been widely utilized in the treatment of various diseases. siRNA can alter gene expression by binding to the target mRNA and thereby inhibiting its translation. This remarkable potential of siRNA makes it a useful candidate, and it has been successively used in the ...
Kalita T, Dezfouli SA, Pandey LM, Uludag H.   +3 more
europepmc   +5 more sources

Inhalable dry powder product (DPP) of mRNA lipid nanoparticles (LNPs) for pulmonary delivery. [PDF]

Drug Deliv Transl Res, 2023
AbstractPulmonary delivery of mRNA via inhalation is a very attractive approach for RNA-based therapy for treatment of lung diseases. In this work, we have demonstrated successful development of an mRNA-lipid nanoparticle (LNP) dry powder product (DPP), wherein the LNPs were spray dried using hydroalcoholic solvent along with mannitol and leucine as ...
Sarode A, Patel P, Vargas-Montoya N, Allawzi A, Zhilin-Roth A, Karmakar S, Boeglin L, Deng H, Karve S, DeRosa F.   +9 more
europepmc   +4 more sources

Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo. [PDF]

iScience
Nucleic acid therapeutics offer tremendous promise for addressing a wide range of common public health conditions. However, the in vivo nucleic acids delivery faces significant biological challenges. Lipid nanoparticles (LNPs) possess several advantages, such as simple preparation, high stability, efficient cellular uptake, endosome escape capabilities,
Zhang T, Yin H, Li Y, Yang H, Ge K, Zhang J, Yuan Q, Dai X, Naeem A, Weng Y, Huang Y, Liang XJ.   +11 more
europepmc   +5 more sources

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability [PDF]

International Journal of Pharmaceutics, 2021
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product ...
Linde Schoenmaker, Dominik Witzigmann, Jayesh A Kulkarni   +2 more
exaly   +6 more sources

Boosting LNP Performance: Higher Concentrations of Lipid Mixtures Improve In Vivo Gene Expression and Storage Stability [PDF]

Pharmaceutics
Background: An efficient formulation of lipid nanoparticles (LNPs) is often considered crucial in the successful development of nucleic acid therapeutics.
Blerina Shkodra, Ashish Muglikar, Janani Thangapandian, Matthias Schumacher, Burcu Binici, Yvonne Perrie   +5 more
doaj   +2 more sources

Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones [PDF]

Nature Communications
Lipid nanoparticles (LNPs) efficiently deliver nucleic acids to cells in vivo and facilitate clinical applications including RNA-based vaccines and therapies.
Stephen T. Moore, Xizhen Lian, Amogh Vaidya, Sumanta Chatterjee, Julien Santelli, Yehui Sun, Lukas Farbiak, Hao Zhu, Daniel J. Siegwart   +8 more
doaj   +2 more sources

Mitochondria-targeted gene delivery using fluorinated lipid nanoparticles to alleviate Leber’s hereditary optic neuropathy [PDF]

Nature Communications
Mutations in mitochondrial DNA (mtDNA) lead to various mitochondrial diseases for which no cure is currently available. Despite the promising potential of mtDNA correction to treat these disorders, the double mitochondrial membranes have proven to be a ...
Yi Wang, Min Zhao, Hai-Xin Xie, Hao-Yuan Yu, Jing-Song Yang, Lu-Xin Qie, Na-Hui Liu, Jia-Qi Chen, Zi-Juan Yi, Tian-Jiao Zhou, Lei Xing, Xian Wu Cheng, Hu-Lin Jiang   +12 more
doaj   +2 more sources

Inflammatory-Targeted Lipid Carrier as a New Nanomaterial to Formulate an Inhaled Drug Delivery System [PDF]

Molecules
There is a pressing need for efficacious therapies in the field of respiratory diseases and infections. Lipid nanocarriers, administered through aerosols, represent a promising tool for maximizing therapeutic concentration in targeted cells and ...
Eleonora Maretti, Federica Gioia, Cecilia Rustichelli, Susanna Molinari, Eliana Leo   +4 more
doaj   +3 more sources