Results 111 to 120 of about 12,002 (336)

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Anionic lipids direct efficient microfluidic encapsulation of stable and functionally active proteins in lipid nanoparticles

Communications Materials
Because proteins do not efficiently pass through the plasma membrane, protein therapeutics are limited to target ligands located at the cell surface or in serum. Lipid nanoparticles can facilitate delivery of polar molecules across a membrane.
Suresh Ambati, Yeqi Li, Matthew K. Whittaker, Eileen J. Kennedy, Wided N. Missaoui, Xiaorong Lin, Zachary A. Lewis, Richard B. Meagher   +7 more
doaj   +1 more source

A microfluidic spray drying approach for developing lipid nanoparticles dry powder via anti-solvent precipitation

Chemical Engineering Journal Advances
The development of novel drug dosage forms with high drug activity and enhanced bioavailability continues to pose a significant challenge in the pharmaceutical industry.
Yipiao Zhang, Yang Liu, Zhu Yang, Chuanpin Chen, Xingchen Zhou, Suhong Chen, Hongliang Zheng   +6 more
doaj   +1 more source

End-to-end optimization of lipid nanoparticle manufacturing for mRNA delivery [PDF]

With the emergence of SARS-CoV-2 in 2020, mRNA vaccines have gained global attention. Currently, lipid nanoparticles (LNPs) are the most clinically advanced drug delivery system for the delivery of nucleic acids.
Giacobbo, Valeria
core   +2 more sources

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Design of PD‐L1‐Targeted Lipid Nanoparticles to Turn on PTEN for Efficient Cancer Therapy

Advanced Science
Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority accumulate in the liver or spleen after injection. Tissue‐specific mRNA delivery can be achieved through modulating LNP properties, such as tuning PEGylation or ...
Yelee Kim, Jiwoong Choi, Eun Hye Kim, Wonbeom Park, Hochung Jang, Yeongji Jang, Sung‐Gil Chi, Dae‐Hyuk Kweon, Kyuri Lee, Sun Hwa Kim, Yoosoo Yang   +10 more
doaj   +1 more source

SAXS/PCS study on the mesoscopic structure of lipid nanoparticle (LNP) formulations for mRNA drug delivery: Comirnaty and drug-free LNP dispersions

, 2023
Lipid Nanoparticles (LNPs) produced by anti-solvent precipitation (ASP) are used in formulations for mRNA drug delivery. The mesoscopic structure of such complex multicomponent and polydisperse nanoparticulate systems is most relevant for their drug delivery properties, medical efficiency, shelf-life, and possible side effects.
Tobias Unruh, Klaus Götz, Carola Vogel, Erik Fröhlich, Andreas Scheurer   +4 more
openaire   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Lipid nanoparticles: Composition, formulation, and application

Molecular Therapy: Methods & Clinical Development
Lipid nanoparticles (LNPs) are lead non-viral vectors for delivering nucleic acids. LNPs can efficiently encapsulate nucleic acids, protect them from degradation, enhance cellular uptake and induce endosome escape, which show high transfection efficiency
Sijia Xu, Zhenzheng Hu, Fenglin Song, Ying Xu, Xuexiang Han   +4 more
semanticscholar   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source