Results 121 to 130 of about 12,002 (336)

Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics

Advanced Science
Lipid Nanoparticles (LNPs) recently emerged as an invaluable RNA delivery platform. With many LNP‐based therapeutics in the pre‐clinical and clinical pipelines, there is extensive research dedicated to improving LNPs.
Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer   +8 more
doaj   +1 more source

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

Vaccines
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great research interest. mRNA vaccines are a potential choice for tumor immunotherapy, due to their ability to directly encode antigen proteins and stimulate a strong immune response ...
Liusheng Wu, Xiaoqiang Li, Xinye Qian, Shuang Wang, Jixian Liu, Jun Yan   +5 more
openaire   +3 more sources

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency

Molecular Therapy: Nucleic Acids
A significant challenge of mRNA-based protein replacement therapies is the diminishing efficacy and escalating toxicity associated with repeated dosing of lipid nanoparticles (LNPs).
Jiyeon Son, Hyunjung Yoo, Joonyoung Park, Hyelim Park, Seung-Eun Chong, Jungeun Lee, Jeewon Kim, Eunyoung Park, Seo-hyeon Bae, Sunhee Kang, Jaeyoung Ban, Soonhwa Song, Eunhye Oh, Heechun Kwak, Hyokyoung Kwon, Jaesung Jung, Narae Lee, Byunghoon Jung, Yuebao Zhang, Diana D. Kang, Shi Du, Young Kee Shin, Yizhou Dong, Jae Uk Jeong   +23 more
doaj   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Molecular Therapy: Nucleic Acids, 2013
Lipid nanoparticles (LNPs) encapsulating short interfering RNAs that target hepatic genes are advancing through clinical trials, and early results indicate the excellent gene silencing observed in rodents and nonhuman primates also translates to humans ...
Barbara L Mui, Ying K Tam, Muthusamy Jayaraman, Steven M Ansell, Xinyao Du, Yuen Yi C Tam, Paulo JC Lin, Sam Chen, Jayaprakash K Narayanannair, Kallanthottathil G Rajeev, Muthiah Manoharan, Akin Akinc, Martin A Maier, Pieter Cullis, Thomas D Madden, Michael J Hope   +15 more
doaj   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

Nature Communications
Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly, as exemplified by the recent ...
Roy Pattipeiluhu, Ye Zeng, Marco M.R.M. Hendrix, Ilja K. Voets, Alexander Kros, Thomas H. Sharp   +5 more
doaj   +1 more source

Liposomal lipid nanoparticles for extrahepatic delivery of mRNA

Nature Communications
Long-circulating, transfection-competent lipid nanoparticle (LNP)-mRNA delivery systems are critical for achieving efficient transfection in extrahepatic tissues.
Miffy Hok Yan Cheng, Yao Zhang, Kevin Fox, Jerry Leung, Colton Strong, E. Kang, Yihang Chen, Michelle Tong, Hemashree Bommadevara, Eric Jan, Owen Yuk Long Ip, Cristina Rodríguez-Rodríguez, K. Saatchi, U. Häfeli, Amir Abdolahzadeh, D. Witzigmann, P. Cullis   +16 more
semanticscholar   +1 more source

Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice [PDF]

One of the biggest challenges for siRNA-based therapeutics is intracellular delivery into the target cell, which can be facilitated by encapsulating siRNA in lipid nanoparticles (LNPs).
Erkens, Sigrun, Escudé Martinez de Castilla, Pol, Estapé Senti, Mariona, Fens, Marcel H., Kooijmans, Sander A.A., Schiffelers, Raymond M., Vader, Pieter, van Weerden, Wytske M.   +7 more
core   +2 more sources