Results 161 to 170 of about 12,002 (336)

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions

Advances in Materials
Lipid nanoparticles (LNPs) have become the dominant drug delivery technology in industry, holding the promise to deliver RNA to up or down‐regulate any protein of interest.
Serena Omo-Lamai, Marco E. Zamora, Manthan N. Patel, Jichuan Wu, Jia Nong, Zhicheng Wang, Alina D Peshkova, Aparajeeta Majumder, Jilian R. Melamed, Liam S. Chase, Eno-Obong Essien, Drew Weissman, V. Muzykantov, O. Marcos-Contreras, J. Myerson, J. Brenner   +15 more
semanticscholar   +1 more source

Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity

Advanced NanoBiomed Research, EarlyView.
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang   +4 more
wiley   +1 more source

mRNA delivery systems for cancer immunotherapy: Lipid nanoparticles and beyond.

Advanced Drug Delivery Reviews
mRNA-based vaccines are emerging as a promising alternative to standard cancer treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid based therapeutics (Onpattro, BNT162b2 and mRNA-1273) has further increased the ...
M. Estapé Sentí, Lucía García Del Valle, R. Schiffelers   +2 more
semanticscholar   +1 more source

Mapping Hydration and Nanoarchitecture in mRNA‐Loaded Lipid Nanoparticles Through Small‐Angle Neutron Scattering

Small Structures
mRNA‐loaded lipid nanoparticles (LNPs) offer significant therapeutic potential for various diseases, yet their structural characteristics and component distribution remain incompletely understood. This study utilizes small‐angle neutron scattering (SANS)
Haikun Liu, Mark Louis P. Vidallon, Sylvain Trépout, Marina Cagnes, Nageshwar Rao Yepuri, Tamim Darwish, Mitchell J. Moon, Pengkai Shi, Aidan P. G. Walsh, Rico F. Tabor, Karlheinz Peter, Liliana de Campo, Xiaowei Wang   +12 more
doaj   +1 more source

Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route

Journal of Nanobiotechnology
The clinical application of conventional medications for hepatocellular carcinoma treatment has been severely restricted by their adverse effects and unsatisfactory therapeutic effectiveness.
Q. Gao, Nanxi Chen, Baoyi Li, Menghang Zu, Ya Ma, Haiting Xu, Zhenhua Zhu, Rui L Reis, Subhas C. Kundu, Bo Xiao   +9 more
semanticscholar   +1 more source

Biomimetic cancer cell membrane engineered lipid nanoparticles for enhanced chemotherapy of homologous malignant tumor

BMC Cancer
Background The advancement of biomimetic drug delivery systems designed for biomedical applications has attracted considerable attention from researchers in recent years.
Fengtian Zhang, Weihong Luo, Zhongjie Min, Longping Wu, Ziyang Wang, Yufei Wang, Wenbin Liao, Yu Liu, Weiliang Chen, Lijuan Wen   +9 more
doaj   +1 more source

Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach

Journal of Nanobiotechnology
RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for treating diverse diseases. However, their potential is commonly hindered by vulnerability to degradation and poor cellular uptake, requiring effective delivery systems ...
Elahe Haghighi, S. Abolmaali, A. Dehshahri, Seyed Ali Mousavi Shaegh, Negar Azarpira, A. Tamaddon   +5 more
semanticscholar   +1 more source

Optimization and Characterization of Aspirin‐ and Ibuprofen‐Loaded Lipid‐Based Nanoparticle Synthesis for Antibacterial Activity and Cytotoxic Effect

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Lipid‐based nanoparticles (LNPs) are favored for drug delivery because of their low toxicity, high biocompatibility, ability to self‐assemble into nanoparticles, and ability to enhance drug bioavailability, thereby improving drug release modulation and pharmacokinetics.
Gulizar Caliskan, Smyrna Ergonul, Zuhal Naz Cansu, Busra Kaplan   +3 more
wiley   +1 more source

Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol

Nature Communications
Lipid nanoparticles (LNPs) are clinically approved for mRNA-based vaccines and liver-targeted siRNA delivery. However, poor nucleic acid delivery efficiency limits their application in extrahepatic tissues and tumors.
Johanna M. Johansson, Hampus Du Rietz, Hampus Hedlund, Hanna C. Eriksson, Erik Oude Blenke, Aditya Pote, Said Harun, Pontus Nordenfelt, Lennart Lindfors, Anders Wittrup   +9 more
doaj   +1 more source

Development of mRNA Lipid Nanoparticles: Targeting and Therapeutic Aspects

International Journal of Molecular Sciences
Lipid nanoparticles (LNPs) have emerged as leading non-viral carriers for messenger RNA (mRNA) delivery in clinical applications. Overcoming challenges in safe and effective mRNA delivery to target tissues and cells, along with controlling release from ...
Yaping Liu, Yingying Huang, Guantao He, Chun Guo, Jinhua Dong, Lin Wu   +5 more
semanticscholar   +1 more source