Results 11 to 20 of about 12,002 (336)

Antitumor Activity of G3139 Lipid Nanoparticles (LNPs) [PDF]

Molecular Pharmaceutics, 2008
G3139, an antisense oligodeoxyribonucleotide (ODN) against Bcl-2, contains two CpG dinucleotides and has shown immunostimulatory activities in preclinical studies. It has been suggested that immunoactivation, rather than antisense activity, is primarily responsible for the therapeutic efficacy of G3139.
Xiaogang, Pan, Li, Chen, Shujun, Liu, Xiaojuan, Yang, Jian-Xin, Gao, Robert J, Lee   +5 more
openaire   +3 more sources

Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. [PDF]

Nat Protoc, 2023
Wang X, Liu S, Sun Y, Yu X, Lee SM, Cheng Q, Wei T, Gong J, Robinson J, Zhang D, Lian X, Basak P, Siegwart DJ.   +12 more
europepmc   +2 more sources

Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles. [PDF]

Int J Pharm X
Oral administration of RNA therapeutics remains a major unsolved challenge due to currently insurmountable biological barriers. Extracellular vesicles (EVs) are natural carriers capable of traversing the intestinal barrier, but inefficient RNA loading ...
Ding N, Daci A, Krasniqi V, Butler R, Goddard A, Guo Q, Zhang Y, Zhong J, Chan KLA, Thanou M, Vllasaliu D.   +10 more
europepmc   +3 more sources

Preparation of aptamer-functionalized lipid nanoparticles (LNPs) encapsulating siRNAs

Protocol Exchange, 2014
Zhang Ge, Heng Wu, Chao Liang, Baosheng Guo, Lingqiang Zhang, Aiping Lu, Ge Zhang   +6 more
openaire   +2 more sources

Size control of lipid nanoparticles via simulation-based design of a microfluidic chip and its effect on mRNA delivery in vitro and in vivo [PDF]

Journal of Nanobiotechnology
The emergence of mRNA-containing lipid nanoparticles (LNPs) during the COVID-19 pandemic has revolutionized vaccine technology and is now being explored for protein replacement therapies. This study aimed to test the hypothesis that LNP size, independent
Bookun Kim, Cheol Hui Park, In-Young Jung, Yeeun Lee, Seong Gi Lim, Donghyun Lee, Seok Joon Kwon, Heebeom Koo   +7 more
doaj   +2 more sources

Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer [PDF]

Scientific Reports, 2022
AbstractLipid nanoparticles (LNPs) for RNA and DNA delivery have attracted considerable attention for their ability to treat a broad range of diseases and to vectorize mRNA for COVID vaccines. LNPs are produced by mixing biomolecules and lipids, which self-assemble to form the desired structure.
Manon Ripoll, Elian Martin, Mathilde Enot, Oscar Robbe, Chiara Rapisarda, Marie-Claire Nicolai, Aurélie Deliot, Patrick Tabeling, Jean-René Authelin, Mostafa Nakach, Pierre Wils   +10 more
openaire   +3 more sources

Thermotropic effects of PEGylated lipids on the stability of HPPH-encapsulated lipid nanoparticles (LNP) [PDF]

Journal of Thermal Analysis and Calorimetry, 2021
In this work, we demonstrate the enhanced thermal and steric stability of lipid-based formulations in the presence of encapsulated HPPH that have demonstrated potential cancer applications in previously presented in vivo studies. Differential scanning calorimeter (DSC) was used to study the phase transitions, and domain formations, and to qualify the ...
Kalyanram, Poornima, Puri, Anu, Gupta, Anju   +2 more
openaire   +2 more sources

In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

Nanomaterials, 2022
Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids.
Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, Federico Perche   +5 more
doaj   +1 more source

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application [PDF]

Advanced Pharmaceutical Bulletin, 2015
Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles.
Neda Naseri, Hadi Valizadeh, Parvin Zakeri-Milani   +2 more
doaj   +1 more source

Lipid-based nanoparticles as novel drug delivery systems for antimicrobial agents [PDF]

The Iranian Journal of Veterinary Science and Technology, 2018
Despite the development of novel drugs and technologies in combating the infectious diseases, they remain as a global health challenge. The use of conventional antimicrobial drugs are always associated with problems such as antimicrobial resistance ...
Ali Rassouli, Alwan Al-Qushawi
doaj   +1 more source