Results 191 to 200 of about 12,002 (336)

H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves

AbstractHighly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 is circulating widely in lactating cows in the United States. Due to the critical need for intervention strategies for this outbreak, we evaluated antibody and cellular immune responses of a clade 2.3.4.4b H5 mRNA-LNP vaccine in calves.
Carine K. Souza, Jefferson J. S. Santos, Paola Boggiatto, Haley Sterle, Bailey Arruda, Mitchell V. Palmer, Alessandra Campos, Jiaojiao Liu, Naiqing Ye, Drew Weissman, Scott E. Hensley, Amy L. Baker   +11 more
openaire   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Evaluation of the Potential Carrier and Controlled Release of Antibiotics by Zinc, Nickel, and Cobalt Ferrite Nanoparticles Encapsulated with Silica and Functionalized with Moxifloxacin Hydrochloride

Particle &Particle Systems Characterization, EarlyView.
The study reveals the inhibitory potential of encapsulated nanoparticles functionalized with moxifloxacin hydrochloride. ABSTRACT Bacterial resistance represents a significant global health threat associated with the development of microbial resistance genes.
Amanda S. Abreu, Stéfanne R. R. Ferreira, Naiara G. Cabral, Romayne P. França, Hanstter H. A. Rezende, Richard Landers, Alexandre Pancotti   +6 more
wiley   +1 more source

Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles. [PDF]

ACS Nano
Bhalotia A, Hutchinson DW, Kosmides T, Nittayacharn P, Mehta M, Iyer A, Cheplyansky A, Takizawa KH, Nidhiry A, Dever AM, Cousens KA, Hwang IM, Ramamurthy G, Exner AA, Karathanasis E.   +14 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

Encapsulation of mRNA in Therapeutics Like Lipid Nanoparticles Probed by Deep-UV Resonance Raman Spectroscopy. [PDF]

Anal Chem
Jin S, Reverdatto SV, Ermolenkov VV, Shekhtman A, Jung YM, Lednev IK.   +5 more
europepmc   +1 more source

FAST‐CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid‐Silica Hybrid Nanoparticles for Therapeutic Genome Editing

Small, EarlyView.
FAST‐CRISPR nanoparticles combine fusogenic lipids and tailored porous silica for rapid and direct cytosolic delivery of CRISPR/Cas9 ribonucleoproteins, bypassing endocytosis. This approach achieves highly efficient genome editing, selectively induces cancer cell apoptosis through multiplex DNA targeting, and effectively suppresses tumor growth in vivo,
Minjong Kim, Kyunghwan Kim, Jihyun Lee, Soyoung Lee, Subin Choi, Soo Ah Park, Euihwan Jeong, Song‐Yi Choi, Hee Ho Park, Tae‐Eun Park, Taejoon Kwon, Kyungjae Myung, Jounghyun Yoo, Seung Woo Cho, Jinmyoung Joo   +14 more
wiley   +1 more source

Decoding pH‐Driven Phase Transition of Lipid Nanoparticles

Small, EarlyView.
Ionizable aminolipids govern lipid nanoparticle (LNP) function through environment‐dependent protonation. Constant‐pH molecular dynamics reveal intrinsic, apparent, and surface pKa${\rm pK}_{\text{a}}$ values within LNP‐mimetic membranes, demonstrating that the LNP lipid environment induces a pronounced downward pKa${\rm pK}_{\text{a}}$ shift exceeding
Marius F.W. Trollmann, Rainer A. Böckmann   +1 more
wiley   +1 more source