Results 241 to 250 of about 12,002 (336)

Mosquito‐Borne Viruses of Clinical Significance

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Mosquito‐borne viruses represent a significant public health concern globally, with rising incidence rates leading to increased morbidity and mortality. This review aims to synthesize current knowledge regarding mosquito‐borne viruses, focusing on their geographic distribution, clinical impact, diagnostic challenges, treatment ...
Donath Damian
wiley   +1 more source

Inhibiting recycling pathways to enhance cellular retention of lipid nanoparticle (LNP)-delivered small interfering RNAs [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

M1 Macrophage‐Derived Small Extracellular Vesicles as Synergistic Nanotherapeutics: Harnessing Intrinsic Anticancer Activity and Drug Delivery Capacity

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
M1 macrophage‐derived small extracellular vesicles (M1‐sEVs) exhibit intrinsic antitumor activity by evading immune surveillance, homing to tumors, and suppressing cancer growth. Leveraging these functions alongside their capacity to deliver therapeutic payloads, dual‐action M1‐sEVs achieve enhanced efficacy in vitro and in vivo. This study establishes
Gaeun Kim, Hyunsu Jeon, Adrian Chao, James Johnston, Runyao Zhu, Courtney Khong, Yichen Liu, Minzhi Liang, Xin Lu, Yichun Wang   +9 more
wiley   +1 more source

Computational Validation of Multi‐Epitope mRNA Vaccine Targeting Streptococcus anginosus Surface Protein (TMPC) as an Effective Alternative Treatment to Reduce Gastric Cancer

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Design process for messenger RNA vaccines. Candidate proteins are initially screened using immunoinformatics, after which selected epitopes are assembled into a multi‐epitope vaccine. The vaccine construct was evaluated through molecular docking, molecular dynamics simulations, and in silico immune simulations, followed by population coverage analysis ...
Fei Zhu, Yuying Luo, Ziyou Zhou, Rongliu Qin, Shiyang Ma, Yizhong Xu, Jie Chen, Pinhua Pan   +7 more
wiley   +1 more source

Targeted Hepatic Delivery of Bioactive Molecules via Nanovesicles: Recent Developments and Emerging Directions. [PDF]

J Pers Med
Canestrale AR, Kholia S, Dimuccio V, Herrera Sanchez MB.   +3 more
europepmc   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge

MedComm, Volume 7, Issue 2, February 2026.
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding, Zai Luo, Liao Zhang, Shaopeng Zhang, Renchao Zhang, Zhengjun Qiu, Chen Huang   +6 more
wiley   +1 more source

Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management. [PDF]

FASEB J
Fan Y, Zhou Y, Zhao J, Zhao Y.
europepmc   +1 more source

Myomerger-derived peptide enhances skeletal muscle tropism and reduces liver transduction of lipid nanoparticles for gene delivery. [PDF]

Mol Ther Nucleic Acids
Ji J, Lipkow E, Anton N, Crucifix C, Eberling P, Laporte J.   +5 more
europepmc   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer‐Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice

MedComm, Volume 7, Issue 2, February 2026.
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang, Longhai Yuan, Yun Xie, Yun Yang, Yanan Zhou, Junbing Wang, Hao Yang, Rui Peng, Jiali Xu, Wenhai Yu, Qing Huang, Wenqi Quan, Baisheng Li, Youchun Wang, Shuaiyao Lu   +14 more
wiley   +1 more source