Results 281 to 290 of about 12,002 (336)

Why do lipid nanoparticles target the liver? Understanding of biodistribution and liver-specific tropism

Molecular Therapy: Methods & Clinical Development
Lipid nanoparticles (LNPs) are now highly effective transporters of nucleic acids to the liver. This liver-specificity is largely due to their association with certain serum proteins, most notably apolipoprotein E (ApoE), which directs them to liver ...
M. Hosseini-Kharat, K. Bremmell, C. Prestidge   +2 more
semanticscholar   +1 more source

Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4

npj Vaccines
Ionizable lipid nanoparticles (LNP) that have enabled the success of messenger RNA (mRNA) vaccines have been shown to be immunostimulatory in the absence of mRNA.
Amanda E. Zelkoski, Zhongyan Lu, Gauthaman Sukumar, C. Dalgard, Hooda Said, M. Alameh, E. Mitre, Allison M. W. Malloy   +7 more
semanticscholar   +1 more source

Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles

Journal of the American Chemical Society
Lipid nanoparticles (LNPs) are widely used for delivering therapeutic nucleic acids, yet the relationship between their internal structure and intracellular behavior, particularly before RNA release, remains unclear.
Yulin Mo, Alexander F. A. Keszei, Shagun Kothari, Heyi Liu, Anni Pan, P. Kim, J. Bu, Albert Kamanzi, David L Dai, Mohammad T. Mazhab-Jafari, Juan Chen, Sabrina Leslie, Gang Zheng   +12 more
semanticscholar   +1 more source

Elucidating the immunogenic mechanisms of Lipid Nanoparticle (LNP) adjuvants 2411

The Journal of Immunology
Abstract Description   Lipid nanoparticles have been shown to be a safe and potent platform for vaccine delivery. When added to subunit protein vaccines, they have the potential to induce long-lasting immunity.
Susan L Secore, Antonia R Bass, Mary Wolf, Andrew Danziger, Silveria Rodriguez, Gregory O’Donnell, Courtney David, Lan Zhang, Nicole L Sullivan   +8 more
openaire   +1 more source

Which Lipid Nanoparticle (LNP) Designs Work? A Simple Kinetic Model Linking LNP Chemical Structure to In Vivo Delivery Performance

ACS Applied Materials & Interfaces
Although lipid nanoparticles (LNPs) are the predominant nanocarriers for short-interfering RNA (siRNA) delivery, most therapies use nearly identical formulations that have taken 30 years to design but lack the diverse property ranges necessary for versatile application.
Esther H. Roh, Millicent O. Sullivan, Thomas H. Epps   +2 more
openaire   +2 more sources

Lipid nanoparticles (LNP): a new technology for fluorescence contrast agents with improved properties

SPIE Proceedings, 2010
Fluorescence imaging is a valuable tool for the study of living systems. It can be used with good resolution from the micro- to the macroscopic range. However, for macroscopic use in living animals or humans, fluorescent probes must overcome several obstacles such as aqueous solubility, suitable circulating lifetime and clearance.
J. Gravier, T. Delmas, A. C. Couffin, F. Navarro, E. Heinrich, F. Vinet, I. Texier   +6 more
openaire   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate
Cell membrane coating (CMC) of nanoparticles (NPs) has emerged as a prominent strategy that has gained significant attention and achieved notable progress across various therapeutic sectors.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chunxia Zhao, Yun Liu   +5 more
semanticscholar   +1 more source

Structure and Morphology of Lipid Nanoparticles for Nucleic Acid Drug Delivery: A Review.

ACS Nano
Lipid nanoparticles (LNPs) are a clinically proven platform for protecting and delivering nucleic acid-based therapeutics. These multicomponent particles self-assemble into a core-shell structure with the nucleic acid cargo encapsulated in its core ...
A. Udepurkar, Cedric Devos, Peter Sagmeister, Francesco Destro, Pavan K. Inguva, Soroush Ahmadi, Etienne Boulais, Yufeng Quan, Richard D. Braatz, Allan S. Myerson   +9 more
semanticscholar   +1 more source

Identification of Cell Receptors Responsible for Recognition and Binding of Lipid Nanoparticles.

Journal of the American Chemical Society
Effective delivery of lipid nanoparticles (LNPs) and their organ- or cell-type targeting are paramount for therapeutic success. Achieving this requires a comprehensive understanding of protein corona dynamics and the identification of cell receptors ...
Didar Baimanov, Jing Wang, Yuchen Liu, Pingping Zheng, Shengtao Yu, Fen Liu, Jian Wang, Diana Boraschi, Yuliang Zhao, Chunying Chen, Liming Wang   +10 more
semanticscholar   +1 more source

Ultrasound-Enhanced Spleen-Targeted mRNA Delivery via Fluorinated PEGylated Lipid Nanoparticles for Immunotherapy.

Angewandte Chemie
Lipid nanoparticles (LNPs) based messenger RNA (mRNA) therapeutics hold immense promise for treating a wide array of diseases, while their nonhepatic organs targeting and insufficient endosomal escape efficiency remain challenges.
Minglong Chen, J. Cen, Qiangqiang Shi, Bing Shao, Jiajia Tan, Xianjun Ye, Zhihua He, Yang Liu, Guoying Zhang, Jinming Hu, Jianqiang Bao, Shiyong Liu   +11 more
semanticscholar   +1 more source