Results 291 to 300 of about 12,002 (336)

Designing lipid nanoparticles using a transformer-based neural network

Nature Nanotechnology
The RNA medicine revolution has been spurred by lipid nanoparticles (LNPs). The effectiveness of an LNP is determined by its lipid components and their ratios; however, experimental optimization is laborious and does not explore the full design space ...
Alvin Chan, Ameya R. Kirtane, Qing Rui Qu, Xisha Huang, Jonathan Woo, Deepak A. Subramanian, Rajib Dey, Rika Semalty, J. Bernstock, Taksim Ahmed, Rowan Honeywell, Charles Hanhurst, Isaac Diaz Becdach, Leah S Prizant, Ashley K. Brown, Hao Song, Justin Law Cobb, Louis DeRidder, Bruna Santos, Miguel Jimenez, Michelle Sun, Yue Huang, Ceara Byrne, G. Traverso   +23 more
semanticscholar   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods
Gene editing has emerged as a promising therapeutic option for treating genetic diseases. However, a central challenge in the field is the safe and efficient delivery of these large editing tools, especially in vivo.
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah M. Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
semanticscholar   +1 more source

Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics

ACS Nano
RNA therapeutics offer a promising approach to cancer treatment by precisely regulating cancer-related genes. While lipid nanoparticles (LNPs) are currently the most advanced nonviral clinically approved vectors for RNA therapeutics, their antitumor ...
Gangyin Zhao, Ye Zeng, Wanli Cheng, S. Karkampouna, Panagiota Papadopoulou, Bochuan Hu, Shuya Zang, Emma Wezenberg, Gabriel Forn-Cuní, Bruno Lopes Bastos, M. K. Julio, A. Kros, B. E. Snaar-Jagalska, Ewa Snaar-Jagalska   +13 more
semanticscholar   +1 more source

Lipid nanoparticle (LNP) components dictate the cellular immune responses to vaccination 3550

The Journal of Immunology
Abstract Description   The type of cellular immune response elicited by a vaccination is key to determination of the success of that vaccination. Historical vaccines have comprised largely of attenuated pathogen or large portions of the pathogen complexed with adjuvant, and most of the data ...
J Paige Gronevelt, Avery Blanks, Seeta Nyayapathy, Julie M. Rumble   +3 more
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Apolipoprotein Fusion Enables Spontaneous Functionalization of mRNA Lipid Nanoparticles with Antibody for Targeted Cancer Therapy

ACS Nano
The mRNA-lipid nanoparticles (mRNA@LNPs) offer a novel opportunity to treat targets previously considered undruggable. Although antibody conjugation is crucial for enhancing the specificity, delivery efficiency, and minimizing the toxicity of mRNA ...
Wonbeom Park, Jiwoong Choi, Jaehyeon Hwang, Suhyun Kim, Yelee Kim, M. Shim, Wooram Park, Seokhyeon Yu, S. Jung, Yoosoo Yang, Dae-Hyuk Kweon   +10 more
semanticscholar   +1 more source

Impact of ionizable lipid type on the pharmacokinetics and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection.

Journal of Controlled Release
Ionizable lipids play a crucial role in mRNA-lipid nanoparticle (LNP) formulations by facilitating mRNA encapsulation, promoting cell uptake, and enhancing endosomal escape of mRNA-LNPs.
Yuxiang Ren, Lihuan Lin, Mohammad Abdallah, Xueting Zhu, Haiyin Liu, Stewart A. Fabb, Thomas Payne, Colin W. Pouton, A. Johnston, Natalie L. Trevaskis   +9 more
semanticscholar   +1 more source

Intelligent Design of Lipid Nanoparticles for Enhanced Gene Therapeutics.

Molecular Pharmaceutics
Lipid nanoparticles (LNPs) are an effective delivery system for gene therapeutics. By optimizing their formulation, the physiochemical properties of LNPs can be tailored to improve tissue penetration, cellular uptake, and precise targeting.
Yichen Yuan, Ying Li, Guo Li, Liqun Lei, Xingxu Huang, Ming Li, Yuan Yao   +6 more
semanticscholar   +1 more source

Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy

Advances in Materials
The advancement of message RNA (mRNA) ‐based immunotherapies for cancer is highly dependent on the effective delivery of RNA (Ribonucleic) payloads using ionizable lipid nanoparticles (LNPs).
Shufen Xu, Yue Xu, Nicholas C Solek, Jingan Chen, Fanglin Gong, Andrew Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, Bowen Li   +10 more
semanticscholar   +1 more source

Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome.

Advanced Drug Delivery Reviews
In the past decade, nucleic acid therapies have seen a boon in development and clinical translation largely due to advances in nanotechnology that have enabled their safe and targeted transport. Nanoparticles can protect nucleic acids from degradation by
Kaitlin Mrksich, Marshall S. Padilla, Michael J. Mitchell   +2 more
semanticscholar   +1 more source

Abstract 1854: Neurotransmitter-derived lipid nanoparticles (LNPs) for brain-targeted drug delivery

Cancer Research
The treatment of central nervous system (CNS) diseases, such as neurodegenerative disorders, brain tumors, brain infections, and stroke, is severely constrained by the blood-brain barrier (BBB) because it prevents the transfer of most of small-molecule drugs and macromolecules (e.g., peptides, gene drugs, and protein drugs) into the brain.
openaire   +1 more source