Delivering schizophrenia-associated MicroRNA137 to the prefrontal cortex by lipid nanoparticles [PDF]
, 2023 Schizophrenia (SCZ) is a complex neuropsychiatric disorder thought to arise from an interplay of environmental and genetic risk factors. The presentation of disease symptomology is heterogenous due to the polygenicity of the disorder.
Palumbo, Michelle
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Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system [PDF]
, 2016 DNA-based gene therapy has considerable therapeutic potential, but the challenges associated with delivery continue to limit progress. Messenger RNA (mRNA) has the potential to provide for transient production of therapeutic proteins, without the need ...
A Akinc +89 more
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Features, applications, and sustainability of lipid nanoparticles in cosmeceuticals
Saudi Pharmaceutical Journal, 2022 Cosmeceuticals are a branch of cosmetic products that forms a bridge between cosmetic and drug products. It is a fast-growing branch of the cosmetic industry, especially after the introduction of novel formulation and manufacturing techniques such as ...
Mohyeddin Assali, Abdel-Naser Zaid
doaj +1 more source
Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles [PDF]
, 2012 One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from nanoparticles for maximum efficacy is ...
Alabi, Christopher A. +3 more
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Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion [PDF]
, 2022 Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several challenges remain before this approach can offer broad clinical translation of mRNA therapeutics.
Aliakbarinodehi, Nima +12 more
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Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]
, 2019 Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn +7 more
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Engineered Dutasteride-Lipid Based Nanoparticle (DST-LNP) System Using Oleic and Stearic Acid for Topical Delivery [PDF]
Bioengineering, 2022 Male pattern baldness (MPB) is a common condition that has a negative impact on the psycho-social health of many men. This study aims to engineer an alcohol-free formulation to cater for individuals who may have had allergic reactions to alcohol-based preparations.
Norhayati Mohamed Noor +4 more
openaire +5 more sources
Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles [PDF]
, 2014 Intracellular protein delivery has potential biotechnological and therapeutic application, but remains technically challenging. In contrast, a plethora of nucleic acid carriers have been developed, with lipid-based nanoparticles (LNPs) among the most ...
Anderson, Daniel Griffith +6 more
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Incorporation of phosphatidylserine improves efficiency of lipid based gene delivery systems [PDF]
, 2022 The essential homeostatic process of dead cell clearance (efferocytosis) is used by viruses in an act of apoptotic mimicry. Among others, virions leverage phosphatidylserine (PS) as an essential "eat me" signal in viral envelopes to increase their ...
Alter, Claudio Luca +6 more
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Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery
Molecules, 2023 Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy.
Yixiang Wang +5 more
doaj +1 more source