Results 51 to 60 of about 12,002 (336)

Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot [PDF]

open access: yes, 2017
Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics.
Antunes, Filipe E.   +12 more
core   +2 more sources

Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery [PDF]

open access: yes, 2023
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19.
Campbell, Richard A.,   +5 more
core   +1 more source

The Importance of Poly(ethylene glycol) and Lipid Structure in Targeted Gene Delivery to Lymph Nodes by Lipid Nanoparticles

open access: yesPharmaceutics, 2020
Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery.
Danijela Zukancic   +5 more
doaj   +1 more source

Synthetic Nanoparticles for Vaccines and Immunotherapy [PDF]

open access: yes, 2015
The immune system plays a critical role in our health. No other component of human physiology plays a decisive role in as diverse an array of maladies, from deadly diseases with which we are all familiar to equally terrible esoteric conditions: HIV ...
Adamina M.   +356 more
core   +1 more source

Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles

open access: yesScientific Reports, 2021
Although proteins have attractive features as biopharmaceuticals, the difficulty in delivering them into the cell interior limits their applicability. Lipid nanoparticles (LNPs) are a promising class of delivery vehicles.
Yusuke Hirai   +4 more
doaj   +1 more source

Lipid nanomaterials-based RNA therapy and cancer treatment

open access: yesActa Pharmaceutica Sinica B, 2023
We summarize the most important advances in RNA delivery and nanomedicine. We describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel drugs. The fundamental properties of the key RNA members are described.
Xingcai Zhang   +4 more
doaj   +1 more source

Short-interference RNAs: becoming medicines [PDF]

open access: yes, 2015
RNA interference is a cellular mechanism by which small molecules of double stranded RNA modulate gene expression acting on the concentration and/or availability of a given messenger RNA.
Jiménez, Ana Isabel   +2 more
core   +1 more source

Assessing Lipid Nanoparticle Protein Corona Formation and Cytocompatibility

open access: yesBritish Journal of Pharmacy, 2023
Lipid nanoparticles(LNPs) represent an emerging new modality for mRNA delivery. Following administration and interaction with blood constituents, LNPs form a corona complex consisting of proteins adsorbed on the surface altering their stability ...
Rand Abdulrahman   +7 more
doaj   +1 more source

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]

open access: yes, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu   +6 more
core   +1 more source

Advances in the delivery of RNA therapeutics: from concept to clinical reality [PDF]

open access: yes, 2017
- The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the ...
Anderson, Daniel Griffith   +2 more
core   +1 more source

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